PMID- 18476631
OWN - NLM
STAT- MEDLINE
DCOM- 20110613
LR  - 20181201
IS  - 2096-7993 (Print)
IS  - 2096-7993 (Linking)
VI  - 22
IP  - 3
DP  - 2008 Feb
TI  - [Expression of Survivin, Caspase-3 and p53 in surgical margin of laryngeal 
      squamous cell carcinoma and their relationship].
PG  - 117-8, 121
AB  - OBJECTIVE: To study the expression of Survivin, Caspase-3 and p53 in surgical 
      margin of laryngeal squamous cell carcinoma (LSCC), and their clinical 
      significance and relationship. METHOD: Immunohistochemistry method was used to 
      detect the expression of Survivin, Caspase-3 and p53 in 116 cases of surgical 
      margin of LSCC. RESULT: According to the recurrence, the patients were divided 
      into four group, recurrence within one year, between one year to three years, 
      between three to five years, more than 5 years (include no recurrence). The 
      expression rate of survivin were 92.9%, 85.0%, 50.0% and 21.1% (P < 0.01) in four 
      groups, respectively. The expression rate of Caspase-3 were 50.0%, 50.0%, 66.7% 
      and 89.5% (P < 0.01). The expression rate of p53 were 57.1%, 37.5%, 45.8% and 
      18.4% (P < 0.05). The expression rate of survivin, caspase-3 and p53 in four 
      groups, respectively, there were significant differences (P < 0.05). CONCLUSION: 
      Expression of Survivin, Caspase-3 and p53 in surgical margin of LSCC may play an 
      important role in the tumorigenesis and development of laryngeal carcinoma. They 
      are feasible for early diagnosis and prognosis estimation.
FAU - Du, Jinduo
AU  - Du J
AD  - Department of Otolaryngology, Affiliated Hospital of Hebei University, Baoding, 
      071000, China. djdlly@yahoo.com.cn
FAU - Sun, Xiaofang
AU  - Sun X
FAU - Tian, Congzhe
AU  - Tian C
FAU - Geng, Xian
AU  - Geng X
FAU - Su, Yajing
AU  - Su Y
LA  - chi
PT  - Journal Article
PL  - China
TA  - Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
JT  - Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical 
      otorhinolaryngology, head, and neck surgery
JID - 101303164
RN  - 0 (BIRC5 protein, human)
RN  - 0 (Inhibitor of Apoptosis Proteins)
RN  - 0 (Survivin)
RN  - 0 (Tumor Suppressor Protein p53)
RN  - EC 3.4.22.- (CASP3 protein, human)
RN  - EC 3.4.22.- (Caspase 3)
SB  - IM
MH  - Aged
MH  - Carcinoma, Squamous Cell/metabolism/*pathology/surgery
MH  - Caspase 3/*metabolism
MH  - Female
MH  - Humans
MH  - Inhibitor of Apoptosis Proteins/*metabolism
MH  - Laryngeal Neoplasms/metabolism/*pathology/surgery
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Recurrence, Local
MH  - Prognosis
MH  - Survivin
MH  - Tumor Suppressor Protein p53/*metabolism
EDAT- 2008/05/15 09:00
MHDA- 2011/06/15 06:00
CRDT- 2008/05/15 09:00
PHST- 2008/05/15 09:00 [pubmed]
PHST- 2011/06/15 06:00 [medline]
PHST- 2008/05/15 09:00 [entrez]
PST - ppublish
SO  - Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2008 Feb;22(3):117-8, 121.