PMID- 18476633
OWN - NLM
STAT- MEDLINE
DCOM- 20110613
LR  - 20080514
IS  - 2096-7993 (Print)
IS  - 2096-7993 (Linking)
VI  - 22
IP  - 3
DP  - 2008 Feb
TI  - [Expression of FHIT gene protein in laryngeal carcinoma].
PG  - 122-3
AB  - OBJECTIVE: To investigate the role and clinical significance of the expression of 
      FHIT gene in development and progression of laryngeal squamous cell 
      carcinoma(LSCC). METHOD: The expression FHIT protein was detected by 
      immunohistochemistry method in the 52 cases with LSCC and 23 cases of adjacent 
      cancer tissues and 10 cases of laryngeal normal mucosa. The expression of FHIT 
      was analyzed in LSCC with different clinicopathological parameters. RESULT: The 
      expression of FHIT in normal tissues (90.0%) and adjacent tissues (78.3%) was 
      obvious higher than that in LSCC (46.2%), which had statistical significant 
      difference (P < 0.01). There was a positive correlation between FHIT expression 
      and TNM staging, lymph node metastasis; but not pathological grade. CONCLUSION: 
      The loss of FHIT expression may be correlated with the development and 
      progression of laryngeal carcinoma. FHIT may be an important tumor suppressor 
      gene in LSCC.
FAU - Cao, Litang
AU  - Cao L
AD  - Department of Otolaryngology, Puren Hospital, Beijing, 100062, China. 
      clt1974@sohu.com
FAU - Chen, Xiaoming
AU  - Chen X
FAU - Wang, Binquan
AU  - Wang B
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
JT  - Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical 
      otorhinolaryngology, head, and neck surgery
JID - 101303164
RN  - 0 (Neoplasm Proteins)
RN  - 0 (fragile histidine triad protein)
RN  - EC 3.6.- (Acid Anhydride Hydrolases)
SB  - IM
MH  - Acid Anhydride Hydrolases/*metabolism
MH  - Adult
MH  - Aged
MH  - Carcinoma, Squamous Cell/*metabolism/pathology
MH  - Female
MH  - Humans
MH  - Laryngeal Neoplasms/*metabolism/pathology
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Proteins/*metabolism
EDAT- 2008/05/15 09:00
MHDA- 2011/06/15 06:00
CRDT- 2008/05/15 09:00
PHST- 2008/05/15 09:00 [pubmed]
PHST- 2011/06/15 06:00 [medline]
PHST- 2008/05/15 09:00 [entrez]
PST - ppublish
SO  - Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2008 Feb;22(3):122-3.