PMID- 18476966
OWN - NLM
STAT- MEDLINE
DCOM- 20080822
LR  - 20080813
IS  - 1464-410X (Electronic)
IS  - 1464-4096 (Linking)
VI  - 102
IP  - 4
DP  - 2008 Aug
TI  - High surgical volume is associated with a lower rate of secondary therapy after 
      radical prostatectomy for localized prostate cancer.
PG  - 463-7
LID - 10.1111/j.1464-410X.2008.07705.x [doi]
AB  - OBJECTIVE: To assess the relationship between surgical volume (SV), defined as 
      the number of radical prostatectomies (RPs) within a calendar year, and the time 
      to secondary therapy (ST) after RP, as this might represent an important 
      determinant of cancer control. PATIENTS AND METHODS: The study included 7937 men 
      treated with RP by 130 urologists between 1989 and 2000. Radiotherapy or any form 
      of hormonal manipulation represented ST. Univariable and multivariable Cox 
      regression analyses was used to evaluate the time to ST after RP. RESULTS: SV was 
      an independent (P = 0.02) predictor of ST-free survival after RP, and the 
      multivariable rate of ST sharply decreased with increasing SV. CONCLUSIONS: The 
      use of ST is inversely proportional to SV of up to 24 RPs per year. A higher 
      annual SV might be indicative of less restrictive use of RP in high-risk patients 
      who eventually require combined treatments.
FAU - Jeldres, Claudio
AU  - Jeldres C
AD  - Cancer Prognostics and Health Outcomes Unit, University of Montreal Health 
      Center, Montreal, Quebec, Canada.
FAU - Suardi, Nazareno
AU  - Suardi N
FAU - Capitanio, Umberto
AU  - Capitanio U
FAU - Montorsi, Francesco
AU  - Montorsi F
FAU - Shariat, Shahrokh F
AU  - Shariat SF
FAU - Perrotte, Paul
AU  - Perrotte P
FAU - Peloquin, Francois
AU  - Peloquin F
FAU - Pharand, Daniel
AU  - Pharand D
FAU - Graefen, Markus
AU  - Graefen M
FAU - Karakiewicz, Pierre I
AU  - Karakiewicz PI
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20080512
PL  - England
TA  - BJU Int
JT  - BJU international
JID - 100886721
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Clinical Competence/*standards
MH  - Epidemiologic Methods
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Prostatectomy/methods/standards/*statistics & numerical data
MH  - Prostatic Neoplasms/mortality/pathology/*surgery
MH  - Quebec/epidemiology
MH  - Survival Rate
MH  - Treatment Outcome
MH  - Workload
EDAT- 2008/05/15 09:00
MHDA- 2008/08/23 09:00
CRDT- 2008/05/15 09:00
PHST- 2008/05/15 09:00 [pubmed]
PHST- 2008/08/23 09:00 [medline]
PHST- 2008/05/15 09:00 [entrez]
AID - BJU7705 [pii]
AID - 10.1111/j.1464-410X.2008.07705.x [doi]
PST - ppublish
SO  - BJU Int. 2008 Aug;102(4):463-7. doi: 10.1111/j.1464-410X.2008.07705.x. Epub 2008 
      May 12.