PMID- 18477141
OWN - NLM
STAT- MEDLINE
DCOM- 20080625
LR  - 20151119
IS  - 1365-4632 (Electronic)
IS  - 0011-9059 (Linking)
VI  - 47
IP  - 6
DP  - 2008 Jun
TI  - The role of the armadillo and sooty mangabey monkey in human leprosy.
PG  - 545-50
LID - 10.1111/j.1365-4632.2008.03722.x [doi]
AB  - BACKGROUND: The armadillo was the first animal model of leprosy. Its role in the 
      transmission of leprosy remains controversial. The sooty mangabey model of 
      leprosy led to the discovery that rhesus monkeys were more susceptible to leprosy 
      when coinfected with simian immunodeficiency virus (SIV), but that leprosy may 
      play a protective role against acquired immunodeficiency syndrome (AIDS) 
      mortality. Recently, molecular methods have been developed for leprosy and may 
      help resolve the role of zoonoses in leprosy. OBSERVATIONS: The recent 
      identification of a case of leprosy in a native-born American on the east coast 
      of the USA and the identification of leprosy as an immunologic reconstitution 
      inflammatory syndrome (IRIS) in human immunodeficiency virus (HIV)-positive cases 
      raise the question of what role zoonoses may play in leprosy. CONCLUSIONS: 
      Leprosy in armadillos and sooty mangabeys has been manipulated by human 
      experimentation. In the case of the armadillo, further study, including molecular 
      techniques, is required to elucidate the role of the armadillo as a zoonosis in 
      human leprosy. Experimentation with the sooty mangabey led to the discovery of an 
      interaction between SIV and leprosy in rhesus monkeys, and prompted the continued 
      investigation of the relationship between HIV and leprosy.
FAU - Hamilton, Heather K
AU  - Hamilton HK
AD  - Department of Dermatology and Baylor Clinic, Baylor College of Medicine, Houston, 
      Texas, USA.
FAU - Levis, William R
AU  - Levis WR
FAU - Martiniuk, Frank
AU  - Martiniuk F
FAU - Cabrera, Aloys
AU  - Cabrera A
FAU - Wolf, John
AU  - Wolf J
LA  - eng
GR  - M01RR00096/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
PL  - England
TA  - Int J Dermatol
JT  - International journal of dermatology
JID - 0243704
SB  - IM
MH  - Animal Experimentation
MH  - Animals
MH  - Armadillos/*microbiology
MH  - Cercocebus atys/*microbiology/virology
MH  - HIV
MH  - HIV Infections/complications/microbiology
MH  - Humans
MH  - Leprosy/complications/transmission/*veterinary/virology
MH  - Macaca mulatta/microbiology/virology
MH  - Monkey Diseases/microbiology/virology
MH  - Mycobacterium leprae/genetics
MH  - Simian Acquired Immunodeficiency Syndrome/complications/microbiology
MH  - Simian Immunodeficiency Virus
MH  - *Zoonoses
RF  - 54
EDAT- 2008/05/15 09:00
MHDA- 2008/06/26 09:00
CRDT- 2008/05/15 09:00
PHST- 2008/05/15 09:00 [pubmed]
PHST- 2008/06/26 09:00 [medline]
PHST- 2008/05/15 09:00 [entrez]
AID - IJD3722 [pii]
AID - 10.1111/j.1365-4632.2008.03722.x [doi]
PST - ppublish
SO  - Int J Dermatol. 2008 Jun;47(6):545-50. doi: 10.1111/j.1365-4632.2008.03722.x.