PMID- 18477552
OWN - NLM
STAT- MEDLINE
DCOM- 20080728
LR  - 20190507
IS  - 1109-3099 (Print)
IS  - 1109-3099 (Linking)
VI  - 7
IP  - 2
DP  - 2008 Apr-Jun
TI  - Severity of coronary artery disease in postmenopausal diabetic women.
PG  - 148-55
AB  - OBJECTIVE: Coronary artery disease (CAD) risk increases in women after the 
      menopause. The aim of this study was to determine the effect of diabetes on the 
      severity of CAD in postmenopausal women undergoing coronary angiography. DESIGN: 
      180 postmenopausal women underwent coronary angiography for suspected CAD. CAD 
      severity was assessed by the number of arteries (0-3) with >50% stenosis in the 
      angiography. Forty-four women had type 2 diabetes mellitus (T2DM). Predisposing 
      risk factors and biochemical and hormonal parameters were recorded. The diabetic 
      women were older (p=0.014), had higher BMI and waist circumference (p<0.001), 
      higher prevalence of hypertension (p=0.002), higher levels of triglycerides, uric 
      acid and higher HOMA-Insulin Resistance Index (p=0.009). RESULTS: The women with 
      diabetes had a higher prevalence of severe stenosis in the angiography: T2DM: 
      0-vessels 25%, 1-vessel disease 18.2%, 2-vessels disease 22.7%, 3-vessels disease 
      34.1%, vs. 49.2%, 23.5%, 22.1%, 5.1% in the non-diabetic women, respectively 
      (p<0.001). Binary logistic regression analysis showed that T2DM was a significant 
      predictor of severe CAD (>or=3 vessel disease) independently of age, family 
      history of T2DM, BMI, time since menopause, hypertension and 
      hypercholesterolemia. Women with T2DM also had lower sex hormone binding globulin 
      (SHBG, p=0.010) levels compared to non-diabetic women. CONCLUSIONS: Diabetic 
      postmenopausal women develop more severe CAD compared to non-diabetic women. This 
      association is independent of other predisposing factors and suggests an 
      independent effect of T2DM on the atherosclerotic process, at least in women 
      after menopause.
FAU - Saltiki, Katerina
AU  - Saltiki K
AD  - Endocrine Unit, Evgenidion Hospital and Department of Clinical Therapeutics, 
      Alexandra University Hospital, Athens, Greece. saze@otenet.gr
FAU - Cimponeriu, Adrianna
AU  - Cimponeriu A
FAU - Lili, Kyriaki
AU  - Lili K
FAU - Peppa, Melpomeni
AU  - Peppa M
FAU - Anastasiou, Eleni
AU  - Anastasiou E
FAU - Alevizaki, Maria
AU  - Alevizaki M
LA  - eng
PT  - Journal Article
PL  - Switzerland
TA  - Hormones (Athens)
JT  - Hormones (Athens, Greece)
JID - 101142469
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Coronary Angiography
MH  - Coronary Artery Disease/diagnostic imaging/*epidemiology/*physiopathology
MH  - Diabetes Mellitus, Type 2/*epidemiology
MH  - Diabetic Angiopathies/diagnostic imaging/epidemiology/physiopathology
MH  - Female
MH  - Humans
MH  - Middle Aged
MH  - *Postmenopause
MH  - Prevalence
MH  - Risk Factors
MH  - *Severity of Illness Index
EDAT- 2008/05/15 09:00
MHDA- 2008/07/29 09:00
CRDT- 2008/05/15 09:00
PHST- 2008/05/15 09:00 [pubmed]
PHST- 2008/07/29 09:00 [medline]
PHST- 2008/05/15 09:00 [entrez]
AID - 10.1007/BF03401506 [doi]
PST - ppublish
SO  - Hormones (Athens). 2008 Apr-Jun;7(2):148-55. doi: 10.1007/BF03401506.