PMID- 18478112
OWN - NLM
STAT- MEDLINE
DCOM- 20080819
LR  - 20211020
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 3
IP  - 5
DP  - 2008 May 14
TI  - Prenatal restraint stress generates two distinct behavioral and neurochemical 
      profiles in male and female rats.
PG  - e2170
LID - 10.1371/journal.pone.0002170 [doi]
LID - e2170
AB  - Prenatal Restraint Stress (PRS) in rats is a validated model of early stress 
      resulting in permanent behavioral and neurobiological outcomes. Although sexual 
      dimorphism in the effects of PRS has been hypothesized for more than 30 years, 
      few studies in this long period have directly addressed the issue. Our group has 
      uncovered a pronounced gender difference in the effects of PRS (stress delivered 
      to the mothers 3 times per day during the last 10 days of pregnancy) on anxiety, 
      spatial learning, and a series of neurobiological parameters classically 
      associated with hippocampus-dependent behaviors. Adult male rats subjected to PRS 
      ("PRS rats") showed increased anxiety-like behavior in the elevated plus maze 
      (EPM), a reduction in the survival of newborn cells in the dentate gyrus, a 
      reduction in the activity of mGlu1/5 metabotropic glutamate receptors in the 
      ventral hippocampus, and an increase in the levels of brain-derived neurotrophic 
      factor (BDNF) and pro-BDNF in the hippocampus. In contrast, female PRS rats 
      displayed reduced anxiety in the EPM, improved learning in the Morris water maze, 
      an increase in the activity of mGlu1/5 receptors in the ventral and dorsal 
      hippocampus, and no changes in hippocampal neurogenesis or BDNF levels. The 
      direction of the changes in neurogenesis, BDNF levels and mGlu receptor function 
      in PRS animals was not consistent with the behavioral changes, suggesting that 
      PRS perturbs the interdependency of these particular parameters and their 
      relation to hippocampus-dependent behavior. Our data suggest that the epigenetic 
      changes in hippocampal neuroplasticity induced by early environmental challenges 
      are critically sex-dependent and that the behavioral outcome may diverge in males 
      and females.
FAU - Zuena, Anna Rita
AU  - Zuena AR
AD  - Perinatal Stress Lab., University Lille 1, Villeneuve d'Ascq, France.
FAU - Mairesse, Jerome
AU  - Mairesse J
FAU - Casolini, Paola
AU  - Casolini P
FAU - Cinque, Carlo
AU  - Cinque C
FAU - Alema, Giovanni Sebastiano
AU  - Alema GS
FAU - Morley-Fletcher, Sara
AU  - Morley-Fletcher S
FAU - Chiodi, Valentina
AU  - Chiodi V
FAU - Spagnoli, Luigi Giusto
AU  - Spagnoli LG
FAU - Gradini, Roberto
AU  - Gradini R
FAU - Catalani, Assia
AU  - Catalani A
FAU - Nicoletti, Ferdinando
AU  - Nicoletti F
FAU - Maccari, Stefania
AU  - Maccari S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080514
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Phosphatidylinositol Phosphates)
RN  - 0 (Receptor, Metabotropic Glutamate 5)
RN  - 0 (Receptors, Metabotropic Glutamate)
RN  - 0 (metabotropic glutamate receptor type 1)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Anxiety
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Cell Differentiation
MH  - Female
MH  - Hippocampus/cytology/metabolism
MH  - Hydrolysis
MH  - *Immobilization
MH  - Learning
MH  - Male
MH  - Phosphatidylinositol Phosphates/metabolism
MH  - Pregnancy
MH  - *Prenatal Exposure Delayed Effects
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptor, Metabotropic Glutamate 5
MH  - Receptors, Metabotropic Glutamate/metabolism
MH  - *Sex Factors
PMC - PMC2366064
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2008/05/15 09:00
MHDA- 2008/08/20 09:00
PMCR- 2008/05/14
CRDT- 2008/05/15 09:00
PHST- 2008/02/06 00:00 [received]
PHST- 2008/04/01 00:00 [accepted]
PHST- 2008/05/15 09:00 [pubmed]
PHST- 2008/08/20 09:00 [medline]
PHST- 2008/05/15 09:00 [entrez]
PHST- 2008/05/14 00:00 [pmc-release]
AID - 08-PONE-RA-03541R1 [pii]
AID - 10.1371/journal.pone.0002170 [doi]
PST - epublish
SO  - PLoS One. 2008 May 14;3(5):e2170. doi: 10.1371/journal.pone.0002170.