PMID- 18478177
OWN - NLM
STAT- MEDLINE
DCOM- 20081201
LR  - 20211020
IS  - 0300-9564 (Print)
IS  - 0300-9564 (Linking)
VI  - 115
IP  - 9
DP  - 2008 Sep
TI  - Investigation of the functional brain-derived neurotrophic factor gene variant 
      Val66MET in migraine.
PG  - 1321-5
LID - 10.1007/s00702-008-0056-1 [doi]
AB  - Experimental studies and investigations of the cerebrospinal fluid in migraineurs 
      have suggested an involvement of brain-derived neurotrophic factor (BDNF) in 
      migraine pathophysiology. In a case-control study approach, the functional 
      Val66MET polymorphism (rs6265) of the BDNF gene was investigated in 265 migraine 
      patients and 153 controls. Genotype and allele frequencies did not differ between 
      healthy subjects and migraineurs. A subgroup analysis for the occurrence of aura 
      or clinical characteristics, including the number of attacks, did not reveal a 
      positive association for the investigated polymorphism. Our data argue against a 
      role of this well characterized BDNF gene variant as a risk factor in migraine.
FAU - Marziniak, Martin
AU  - Marziniak M
AD  - Department of Neurology, University of Wurzburg, Wurzburg, Germany. 
      marzinia@uni-muenster.de
FAU - Herzog, Anna Laura
AU  - Herzog AL
FAU - Mossner, Rainald
AU  - Mossner R
FAU - Sommer, Claudia
AU  - Sommer C
LA  - eng
PT  - Journal Article
DEP - 20080514
PL  - Austria
TA  - J Neural Transm (Vienna)
JT  - Journal of neural transmission (Vienna, Austria : 1996)
JID - 9702341
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - AE28F7PNPL (Methionine)
RN  - HG18B9YRS7 (Valine)
SB  - IM
EIN - J Neural Transm. 2009 Sep;116(9):1189. Herzog, Andrea [corrected to Herzog, Anna 
      Laura]
MH  - Adult
MH  - Aged
MH  - Amino Acid Sequence/genetics
MH  - Amino Acid Substitution/genetics
MH  - Brain/*metabolism/physiopathology
MH  - Brain-Derived Neurotrophic Factor/*genetics/metabolism
MH  - Case-Control Studies
MH  - DNA Mutational Analysis
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease/*genetics
MH  - Genetic Testing
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Methionine/genetics
MH  - Middle Aged
MH  - Migraine Disorders/*genetics/*metabolism/physiopathology
MH  - Polymorphism, Genetic/*genetics
MH  - Risk Factors
MH  - Valine/genetics
EDAT- 2008/05/15 09:00
MHDA- 2008/12/17 09:00
CRDT- 2008/05/15 09:00
PHST- 2008/01/07 00:00 [received]
PHST- 2008/04/20 00:00 [accepted]
PHST- 2008/05/15 09:00 [pubmed]
PHST- 2008/12/17 09:00 [medline]
PHST- 2008/05/15 09:00 [entrez]
AID - 10.1007/s00702-008-0056-1 [doi]
PST - ppublish
SO  - J Neural Transm (Vienna). 2008 Sep;115(9):1321-5. doi: 10.1007/s00702-008-0056-1. 
      Epub 2008 May 14.