PMID- 18478184
OWN - NLM
STAT- MEDLINE
DCOM- 20081030
LR  - 20131121
IS  - 0141-5492 (Print)
IS  - 0141-5492 (Linking)
VI  - 30
IP  - 9
DP  - 2008 Sep
TI  - Salicylideneamino-2-thiophenol inhibits inflammatory mediator genes (RANTES, 
      MCP-1, IL-8 and HIF-1alpha) expression induced by tert-butyl hydroperoxide via 
      MAPK pathways in rat peritoneal macrophages.
PG  - 1553-8
LID - 10.1007/s10529-008-9744-z [doi]
AB  - Salicylideneamino-2-thiophenol (Sal) regulated the redox status and the 
      expression of chemokines induced by tert-butyl hydroperoxide (t-BHP). Sal (100 
      microM) increased reduced/oxidized glutathione (GSH/GSSG) ratios and thiol (SH) 
      levels by 210 and 157%, respectively, and decreased reactive oxygen species (ROS) 
      levels by 60% in t-BHP-treated macrophages. The inductions of regulated upon 
      activation, normal T-cell expressed and secreted (RANTES), monocyte 
      chemoattractant protein-1 (MCP-1), interleukin-8 (IL-8) and hypoxia inducible 
      factor-1alpha (HIF-1alpha) by t-BHP (10 microM) were decreased to 250, 80, 80 and 
      500% by Sal (100 microM), respectively. In the Sal signaling pathway, c-Jun 
      N-terminal kinases (JNK), extracellular signal-regulated kinases (ERK) and p38 
      signaling protein modulation were decreased by 67, 69 and 119%, respectively, by 
      Sal at 100 microM. Sal (100 microM) also altered cytosol and nuclear NF-kappaB 
      protein expression by 169 and 5%, respectively. Sal also attenuated NF-kappaB 
      nuclear binding activity. Sal thus has a protective effect against t-BHP-induced 
      inflammation and that this, in part, is due to the inhibition of the production 
      of RANTES, MCP-1, IL-8 and HIF-1alpha via the modulation of the NF-kappaB and 
      mitogen-activated protein kinase (MAPK) pathways.
FAU - Chung, Jin
AU  - Chung J
AD  - Department of Microbiology, School of Dentistry and Research Institute for Oral 
      Biotechnology, Busan, Korea.
FAU - Lee, Hwa Sun
AU  - Lee HS
FAU - Chung, Hae Young
AU  - Chung HY
FAU - Yoon, Taek Rim
AU  - Yoon TR
FAU - Kim, Hyung Keun
AU  - Kim HK
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080514
PL  - Netherlands
TA  - Biotechnol Lett
JT  - Biotechnology letters
JID - 8008051
RN  - 0 (Chemokine CCL2)
RN  - 0 (Chemokine CCL5)
RN  - 0 (Hypoxia-Inducible Factor 1, alpha Subunit)
RN  - 0 (Interleukin-8)
RN  - 0 (NF-kappa B)
RN  - 0 (Phenols)
RN  - 0 (RNA, Messenger)
RN  - 0 (Salicylates)
RN  - 0 (Sulfhydryl Compounds)
RN  - 0 (salicylideneamino-2-thiophenol)
RN  - 7K011JR4T0 (thiophenol)
RN  - 955VYL842B (tert-Butylhydroperoxide)
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinases)
RN  - GAN16C9B8O (Glutathione)
RN  - O414PZ4LPZ (Salicylic Acid)
SB  - IM
MH  - Animals
MH  - Chemokine CCL2/genetics/metabolism
MH  - Chemokine CCL5/genetics/metabolism
MH  - Gene Expression Regulation/*drug effects
MH  - Glutathione/metabolism
MH  - Hypoxia-Inducible Factor 1, alpha Subunit/genetics/metabolism
MH  - Inflammation/*genetics
MH  - Interleukin-8/genetics/metabolism
MH  - Macrophages, Peritoneal/*drug effects/*enzymology
MH  - Mitogen-Activated Protein Kinases/*metabolism
MH  - NF-kappa B/metabolism
MH  - Phenols/chemistry/*pharmacology
MH  - RNA, Messenger/genetics/metabolism
MH  - Rats
MH  - Salicylates/chemistry/*pharmacology
MH  - Salicylic Acid/chemistry
MH  - Sulfhydryl Compounds/chemistry/*pharmacology
MH  - tert-Butylhydroperoxide/*pharmacology
EDAT- 2008/05/15 09:00
MHDA- 2008/10/31 09:00
CRDT- 2008/05/15 09:00
PHST- 2008/02/01 00:00 [received]
PHST- 2008/04/28 00:00 [accepted]
PHST- 2008/04/24 00:00 [revised]
PHST- 2008/05/15 09:00 [pubmed]
PHST- 2008/10/31 09:00 [medline]
PHST- 2008/05/15 09:00 [entrez]
AID - 10.1007/s10529-008-9744-z [doi]
PST - ppublish
SO  - Biotechnol Lett. 2008 Sep;30(9):1553-8. doi: 10.1007/s10529-008-9744-z. Epub 2008 
      May 14.