PMID- 18478351
OWN - NLM
STAT- MEDLINE
DCOM- 20081211
LR  - 20211020
IS  - 0165-7380 (Print)
IS  - 0165-7380 (Linking)
VI  - 32
IP  - 7
DP  - 2008 Oct
TI  - Effects of parenteral supply of iron and copper on hematology, weight gain, and 
      health in neonatal dairy calves.
PG  - 553-61
LID - 10.1007/s11259-008-9058-6 [doi]
AB  - The objective of the present study was to examine the effects of parenteral 
      administration of iron and copper on hematological parameters, weight gain, and 
      health of neonatal dairy calves in the period when iron and copper deficiency 
      could be existed. Twenty-four Holstein calves were used for the experiment and 
      randomly assigned to four different treatments. Treatments consisted of (1) 
      control (no injections of Fe and Cu), (2) test 1 (1000 mg Fe as fe-dextran was 
      injected to each calf at day 2 of age), (3) test 2 (160 mg Cu as 
      methionine-copper complex was injected to each calf at day 14 of age), and (4) 
      test 3 (Fe and Cu were injected to each calf as mentioned previously). Blood 
      samples were collected from all of the calves within 24-48 hours after birth and 
      at 7, 14, 21 and 28 days of age for measuring hematological parameters and within 
      24-48 hours after birth and at 14, 21 and 28 days of age for the determination of 
      iron, copper, TIBC concentrations, and AST activity. Anti-coagulated blood was 
      analyzed shortly after collection for: number of red blood cell (RBC), hemoglobin 
      (Hb), heamatocrit (HCT), total leukocyte count (WBC), Platelet (Plt), MCH, MCV, 
      MCHC, and differential leukocyte counts. The amounts of iron, copper, TIBC, and 
      AST were measured in serum. Group had significant effects on the amounts of HCT, 
      RBC, hemoglobin, MCV, neutrophil, weekly weight gain, and daily gain during each 
      week (p < 0.05). Sampling time had significant effects on the amounts of RBC, 
      MCV, MCH, MCHC, WBC, neutrophil, lymphocyte, monocyte, platelet, fibrinogen, 
      copper, TIBC, AST, weight, weekly gain and, daily gain during each week (p < 
      0.05). significant interactions between sampling time and group were seen for 
      HCT, RBC, hemoglobin, MCV, platelet, total protein, fibrinogen, iron, and TIBC (p 
      < 0.05). Improved RBC parameters and MCV were seen in calves of group 4 (test 3) 
      in comparing with control group. Total and daily gains were also significantly 
      improved in test groups in comparing with control group (p < 0.05). No 
      significant difference was seen for the days of treatment between groups.
FAU - Heidarpour Bami, M
AU  - Heidarpour Bami M
AD  - Department of Clinical Sciences and Center of Excellence in Ruminant Abortion and 
      Neonatal Mortality, School of Veterinary Medicine, Ferdowsi University of 
      Mashhad, P. O. Box: 91775-1793, Mashhad, Iran.
FAU - Mohri, M
AU  - Mohri M
FAU - Seifi, H A
AU  - Seifi HA
FAU - Alavi Tabatabaee, A A
AU  - Alavi Tabatabaee AA
LA  - eng
PT  - Controlled Clinical Trial
PT  - Journal Article
DEP - 20080514
PL  - Switzerland
TA  - Vet Res Commun
JT  - Veterinary research communications
JID - 8100520
RN  - 0 (Trace Elements)
RN  - 789U1901C5 (Copper)
RN  - E1UOL152H7 (Iron)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Cattle/*blood/*growth & development
MH  - Copper/*administration & dosage/*pharmacology
MH  - Dairying
MH  - Injections
MH  - Iron/*administration & dosage/*pharmacology
MH  - Trace Elements/administration & dosage/pharmacology
MH  - Weight Gain/drug effects
EDAT- 2008/05/15 09:00
MHDA- 2008/12/17 09:00
CRDT- 2008/05/15 09:00
PHST- 2007/08/30 00:00 [received]
PHST- 2008/04/02 00:00 [accepted]
PHST- 2008/05/15 09:00 [pubmed]
PHST- 2008/12/17 09:00 [medline]
PHST- 2008/05/15 09:00 [entrez]
AID - 10.1007/s11259-008-9058-6 [doi]
PST - ppublish
SO  - Vet Res Commun. 2008 Oct;32(7):553-61. doi: 10.1007/s11259-008-9058-6. Epub 2008 
      May 14.