PMID- 18479766
OWN - NLM
STAT- MEDLINE
DCOM- 20090722
LR  - 20181201
IS  - 1872-6976 (Electronic)
IS  - 0167-4943 (Linking)
VI  - 48
IP  - 3
DP  - 2009 May-Jun
TI  - Hyperhomocysteinemia and Alzheimer's disease: A systematic review.
PG  - 425-30
LID - 10.1016/j.archger.2008.03.009 [doi]
AB  - Hyperhomocysteinemia (HHcy) is supposed to be one of the modifiable risk factors 
      that, if treated, may delay the onset of Alzheimer's disease (AD). The relation 
      between serum homocysteine (Hcy) and vitamin levels during AD and its preclinical 
      phase was systematically reviewed. Searches through large literature and trial 
      databases were conducted. Data were extracted from studies and, after quality 
      assessment, analyzed using a meta-analysis software package. Nine qualitatively 
      good case-control studies were identified. The pooled standardized mean 
      difference (PSMD) of Hcy levels (631 patients, 703 controls) was 1.04 
      (0.44-1.63), indicating higher Hcy levels in AD patients. Levels of folate 
      (PSMD=0.65) (0.34-0.95) (387 patients, 312 controls) and vitamin B(12) 
      (PSMD=0.50) (-0.05-1.06) (387 patients, 312 controls) were lower in AD patients. 
      Vitamin B(6) levels were evaluated in 1 case-control study and were not 
      significantly lower in AD patients. Analysis of prospective cohort studies (2569 
      subjects) revealed a pooled relative risk for AD in HHcy of 2.5 (1.38-4.56, 
      p<0.01). No specific randomized controlled trials (RCTs) concerning Hcy-lowering 
      therapy and AD-risk were identified. Prospective studies on the relation between 
      folate, vitamins B(6) and B(12) levels and the risk of developing AD are 
      warranted, preferably in the form of RCTs.
FAU - Van Dam, Floris
AU  - Van Dam F
AD  - Jellinek-Mentrum City Center Psychiatric Outpatient Clinic, Roetersstraat 210, 
      1018 WE, Amsterdam, The Netherlands. fvandam@email.com
FAU - Van Gool, Willem A
AU  - Van Gool WA
LA  - eng
PT  - Journal Article
PT  - Review
PT  - Systematic Review
DEP - 20080513
PL  - Netherlands
TA  - Arch Gerontol Geriatr
JT  - Archives of gerontology and geriatrics
JID - 8214379
RN  - 8059-24-3 (Vitamin B 6)
RN  - 935E97BOY8 (Folic Acid)
RN  - P6YC3EG204 (Vitamin B 12)
SB  - IM
MH  - Alzheimer Disease/blood/diagnosis/drug therapy/*prevention & control
MH  - Folic Acid/blood
MH  - Humans
MH  - Hyperhomocysteinemia/*complications/drug therapy
MH  - Risk Factors
MH  - Vitamin B 12/blood
MH  - Vitamin B 6/blood
RF  - 48
EDAT- 2008/05/16 09:00
MHDA- 2009/07/23 09:00
CRDT- 2008/05/16 09:00
PHST- 2007/08/27 00:00 [received]
PHST- 2008/03/10 00:00 [revised]
PHST- 2008/03/14 00:00 [accepted]
PHST- 2008/05/16 09:00 [pubmed]
PHST- 2009/07/23 09:00 [medline]
PHST- 2008/05/16 09:00 [entrez]
AID - S0167-4943(08)00071-X [pii]
AID - 10.1016/j.archger.2008.03.009 [doi]
PST - ppublish
SO  - Arch Gerontol Geriatr. 2009 May-Jun;48(3):425-30. doi: 
      10.1016/j.archger.2008.03.009. Epub 2008 May 13.