PMID- 18481072
OWN - NLM
STAT- MEDLINE
DCOM- 20081023
LR  - 20211020
IS  - 0340-1855 (Print)
IS  - 0340-1855 (Linking)
VI  - 67
IP  - 4
DP  - 2008 Jul
TI  - [Immune reconstitution inflammatory syndrome (IRIS)].
PG  - 284, 286-9
LID - 10.1007/s00393-008-0299-0 [doi]
AB  - Overwhelming immune reaction resulting in granulomatous inflammation after 
      infection with opportunistic pathogens has been termed immune reconstitution 
      inflammatory syndrome (IRIS). IRIS has mainly been described in patients with 
      human immunodeficiency virus (HIV). However, IRIS is not restricted to 
      HIV-patients and may occur in other infections and immunodeficiencies. In our 
      clinic, we experienced a Whipple's disease patient with IRIS. IRIS occurs mainly 
      after initiation of the highly active anti-retroviral therapy (HAART). Soon after 
      HAART initiation, a marked inflammatory reaction can occur, triggered by 
      restoration of pathogen-specific immunity. IRIS may be targeted by various 
      infective antigens, dead or dying infective antigens, host antigens, tumor 
      antigens and other antigens, giving rise to a heterogenous range of clinical 
      manifestations. Treatment should be optimized for the associated condition and 
      initiated immediately. Glucocorticoids should be used in patients who are 
      severely affected by IRIS.
FAU - Wagner, A D
AU  - Wagner AD
AD  - Abteilung fur Nieren- und Hochdruckerkrankungen, Medizinische Hochschule 
      Hannover, Carl-Neuberg-Strasse 1, 30625 Hannover, Deutschland. 
      wagner.annette@mh-hannover.de
LA  - ger
PT  - Case Reports
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Das entzundliche Immunrekonstitutionssyndrom.
PL  - Germany
TA  - Z Rheumatol
JT  - Zeitschrift fur Rheumatologie
JID - 0414162
SB  - IM
MH  - Acquired Immunodeficiency Syndrome/*diagnosis/*drug therapy
MH  - Antiretroviral Therapy, Highly Active/*adverse effects
MH  - Humans
MH  - Immune Reconstitution Inflammatory Syndrome/*diagnosis/*therapy
MH  - Rheumatology/*methods/trends
RF  - 51
EDAT- 2008/05/16 09:00
MHDA- 2008/10/24 09:00
CRDT- 2008/05/16 09:00
PHST- 2008/05/16 09:00 [pubmed]
PHST- 2008/10/24 09:00 [medline]
PHST- 2008/05/16 09:00 [entrez]
AID - 10.1007/s00393-008-0299-0 [doi]
PST - ppublish
SO  - Z Rheumatol. 2008 Jul;67(4):284, 286-9. doi: 10.1007/s00393-008-0299-0.