PMID- 18481177
OWN - NLM
STAT- MEDLINE
DCOM- 20090211
LR  - 20211020
IS  - 1573-2568 (Electronic)
IS  - 0163-2116 (Linking)
VI  - 54
IP  - 1
DP  - 2009 Jan
TI  - Peptides derived from a soluble molecule of the human leukocyte antigen (HLA) 
      class I cause apoptosis in gastric cancer cell lines.
PG  - 63-9
LID - 10.1007/s10620-008-0308-9 [doi]
AB  - We have reported that the levels of the soluble molecule of the human leukocyte 
      antigen class I (sHLA-I) in patients with advanced gastric cancer were 
      significantly lower than those in patients with cancer in the early stages. 
      However, the effect of sHLA-I on gastric cancer cells has not been elucidated. 
      Using human gastric cancer cell lines, MKN28, MKN45, and MKN74, we evaluated the 
      effects of sHLA-I on cell growth, DNA synthesis, and apoptosis induction. Three 
      types of synthesized peptides derived from HLA-I were also examined for their 
      capacity to induce apoptosis. sHLA-I and a synthesized peptide, nos. 220-232 of 
      the alpha3 domain of HLA-B7, caused cell growth inhibition by inducing apoptosis 
      in human gastric cancer cells. This peptide also inhibited the in vivo growth of 
      cancer dissemination caused by an intraperitoneal injection of MKN45 into severe 
      combined immunodeficient mice. In conclusion, sHLA-I and the peptides derived 
      from HLA-I cause apoptosis in human gastric cancer cell lines.
FAU - Shimura, Tatsuo
AU  - Shimura T
AD  - Department of General Surgical Science (Surgery I), Gunma University Graduate 
      School of Medicine, 3-39-15 Showa-machi, Maebashi, Gunma, 371-8511, Japan. 
      tshimura@showa.gunma-u.ac.jp
FAU - Suehiro, Taketoshi
AU  - Suehiro T
FAU - Suzuki, Hideki
AU  - Suzuki H
FAU - Mochida, Yasushi
AU  - Mochida Y
FAU - Okada, Koji
AU  - Okada K
FAU - Mochiki, Erito
AU  - Mochiki E
FAU - Kuwano, Hiroyuki
AU  - Kuwano H
LA  - eng
PT  - Journal Article
DEP - 20080515
PL  - United States
TA  - Dig Dis Sci
JT  - Digestive diseases and sciences
JID - 7902782
RN  - 0 (HLA Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Peptides)
SB  - IM
MH  - Adenocarcinoma/*pathology
MH  - Animals
MH  - Apoptosis/*drug effects
MH  - Cell Line, Tumor
MH  - HLA Antigens/*pharmacology
MH  - Histocompatibility Antigens Class I/pharmacology
MH  - Humans
MH  - Killer Cells, Natural/drug effects
MH  - Mice
MH  - Mice, Nude
MH  - Peptides/*pharmacology
MH  - Stomach Neoplasms/*pathology
MH  - T-Lymphocytes, Cytotoxic/drug effects
MH  - Xenograft Model Antitumor Assays
EDAT- 2008/05/16 09:00
MHDA- 2009/02/12 09:00
CRDT- 2008/05/16 09:00
PHST- 2006/07/14 00:00 [received]
PHST- 2008/04/17 00:00 [accepted]
PHST- 2008/05/16 09:00 [entrez]
PHST- 2008/05/16 09:00 [pubmed]
PHST- 2009/02/12 09:00 [medline]
AID - 10.1007/s10620-008-0308-9 [doi]
PST - ppublish
SO  - Dig Dis Sci. 2009 Jan;54(1):63-9. doi: 10.1007/s10620-008-0308-9. Epub 2008 May 
      15.