PMID- 18482868
OWN - NLM
STAT- MEDLINE
DCOM- 20081230
LR  - 20191210
IS  - 1471-4914 (Print)
IS  - 1471-4914 (Linking)
VI  - 14
IP  - 6
DP  - 2008 Jun
TI  - The molecular genetics of type 1 diabetes: new genes and emerging mechanisms.
PG  - 268-75
LID - 10.1016/j.molmed.2008.04.002 [doi]
AB  - Susceptibility to type 1 diabetes (T1D) is determined by complex interactions 
      between several genetic loci and environmental factors. Alleles at the human 
      leukocyte antigen (HLA) locus explain up to 50% of the familial clustering of 
      T1D, and the remainder is contributed to by multiple loci, of which only four 
      were known until recently. First-stage results of genome-wide association (GWA) 
      studies performed with high-density genotyping arrays have already produced four 
      novel loci and the promise that, with the completion of the second stage of the 
      GWA studies, most of the genetic basis of T1D will be known. We will review what 
      is known to date about the mechanisms of genetic susceptibility to T1D, with 
      special emphasis on possible diagnostic and therapeutic applications of these 
      recent genetic findings.
FAU - Ounissi-Benkalha, Houria
AU  - Ounissi-Benkalha H
AD  - Endocrine Genetics Laboratory, McGill University Health Center, Montreal 
      Children's Hospital Research Institute, 2300 Tupper, Montreal, Quebec H3H 1P3, 
      Canada.
FAU - Polychronakos, Constantin
AU  - Polychronakos C
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20080514
PL  - England
TA  - Trends Mol Med
JT  - Trends in molecular medicine
JID - 100966035
RN  - 0 (Antigens, CD)
RN  - 0 (CTLA-4 Antigen)
RN  - 0 (CTLA4 protein, human)
RN  - 0 (HLA Antigens)
RN  - 0 (Insulin)
RN  - 0 (Receptors, Interleukin-2)
RN  - EC 1.14.15.18 (25-Hydroxyvitamin D3 1-alpha-Hydroxylase)
RN  - EC 3.1.3.48 (PTPN2 protein, human)
RN  - EC 3.1.3.48 (Protein Tyrosine Phosphatase, Non-Receptor Type 2)
RN  - EC 3.6.1.- (IFIH1 protein, human)
RN  - EC 3.6.4.13 (DEAD-box RNA Helicases)
RN  - EC 3.6.4.13 (Interferon-Induced Helicase, IFIH1)
SB  - IM
MH  - 25-Hydroxyvitamin D3 1-alpha-Hydroxylase/genetics
MH  - Alleles
MH  - Antigens, CD/genetics
MH  - CTLA-4 Antigen
MH  - DEAD-box RNA Helicases/genetics
MH  - Diabetes Mellitus, Type 1/*genetics
MH  - Genetic Linkage
MH  - *Genetic Predisposition to Disease
MH  - Genome-Wide Association Study
MH  - HLA Antigens/genetics
MH  - Humans
MH  - Insulin/genetics
MH  - Interferon-Induced Helicase, IFIH1
MH  - Linkage Disequilibrium
MH  - Protein Tyrosine Phosphatase, Non-Receptor Type 2/genetics
MH  - Receptors, Interleukin-2/genetics
RF  - 71
EDAT- 2008/05/17 09:00
MHDA- 2008/12/31 09:00
CRDT- 2008/05/17 09:00
PHST- 2008/01/11 00:00 [received]
PHST- 2008/04/08 00:00 [revised]
PHST- 2008/04/08 00:00 [accepted]
PHST- 2008/05/17 09:00 [pubmed]
PHST- 2008/12/31 09:00 [medline]
PHST- 2008/05/17 09:00 [entrez]
AID - S1471-4914(08)00106-8 [pii]
AID - 10.1016/j.molmed.2008.04.002 [doi]
PST - ppublish
SO  - Trends Mol Med. 2008 Jun;14(6):268-75. doi: 10.1016/j.molmed.2008.04.002. Epub 
      2008 May 14.