PMID- 18482959
OWN - NLM
STAT- MEDLINE
DCOM- 20080826
LR  - 20080516
IS  - 0956-4624 (Print)
IS  - 0956-4624 (Linking)
VI  - 19
IP  - 5
DP  - 2008 May
TI  - Oral manifestations after immune reconstitution in HIV patients on HAART.
PG  - 305-8
LID - 10.1258/ijsa.2007.007261 [doi]
AB  - In order to verify possible association between immune reconstitution 
      inflammatory syndrome (IRIS) and oral manifestations (OMs), we selected AIDS 
      patients who had low CD4 count before the initiation of highly active 
      antiretroviral therapy (HAART) and who returned three months later for therapy 
      evaluation. The oral lesions observed three months after the initiation of HAART 
      were evaluated and associated with the type of antiretroviral therapy (ART), CD4 
      count and HIV-RNA load levels (before and three months after HAART initiation). A 
      total of 105 patients matched the selected criteria. Immune reconstitution (IR) 
      was identified in 35.2%. Among these patients, the mean CD4 cell count rose from 
      105.97 to 330.29 and the mean viral load dropped from 168.005 (log 5.22) to 
      21.852 (log 4.33). There was no significant difference in age (P = 0.78), sex (P 
      = 0.41) or previous history of ART (P = 0.55) between IR and non-IR patients. In 
      the IR group, the most common OM was parotid enlargement (57.14%) (P = 0.019), 
      whereas in the non-IR group candidiasis (46.15%) was the most common OM. The 
      results of our study suggest that the parotid gland enlargement found in the 
      studied population might be an IRIS event, as it was found in patients with IR 
      three months after the initiation of HAART.
FAU - Ortega, Karem L
AU  - Ortega KL
AD  - Department of Oral Pathology, Special Care Dentistry Center, University of Sao 
      Paulo, Sao Paulo, SP, Brazil. klortega@usp.br
FAU - Ceballos-Salobrena, Alejandro
AU  - Ceballos-Salobrena A
FAU - Gaitan-Cepeda, Luis A
AU  - Gaitan-Cepeda LA
FAU - Magalhaes, Marina G
AU  - Magalhaes MG
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Int J STD AIDS
JT  - International journal of STD & AIDS
JID - 9007917
RN  - 0 (Anti-HIV Agents)
SB  - IM
MH  - Anti-HIV Agents/adverse effects/*therapeutic use
MH  - *Antiretroviral Therapy, Highly Active
MH  - CD4-CD8 Ratio
MH  - HIV Infections/complications/*drug therapy/*immunology
MH  - Humans
MH  - Immune Reconstitution Inflammatory Syndrome/epidemiology/*etiology
MH  - Immune Tolerance/drug effects
MH  - Inflammation/*chemically induced/pathology
MH  - Mouth Diseases/epidemiology/*microbiology
MH  - Opportunistic Infections/epidemiology/*etiology
MH  - Prevalence
EDAT- 2008/05/17 09:00
MHDA- 2008/08/30 09:00
CRDT- 2008/05/17 09:00
PHST- 2008/05/17 09:00 [pubmed]
PHST- 2008/08/30 09:00 [medline]
PHST- 2008/05/17 09:00 [entrez]
AID - 19/5/305 [pii]
AID - 10.1258/ijsa.2007.007261 [doi]
PST - ppublish
SO  - Int J STD AIDS. 2008 May;19(5):305-8. doi: 10.1258/ijsa.2007.007261.