PMID- 18483155
OWN - NLM
STAT- MEDLINE
DCOM- 20081002
LR  - 20211020
IS  - 0013-7227 (Print)
IS  - 0013-7227 (Linking)
VI  - 149
IP  - 9
DP  - 2008 Sep
TI  - Regulation of pseudosexual behavior in the parthenogenetic whiptail lizard, 
      Cnemidophorus uniparens.
PG  - 4622-31
LID - 10.1210/en.2008-0214 [doi]
AB  - Neuroendocrine mechanisms underlying complementary behaviors like male-typical 
      mounting and female-typical receptivity are most often studied independently in 
      males and females, respectively. Cnemidophorus uniparens is a unisexual lizard 
      species consisting only of females that alternately express male- and female-like 
      pseudosexual behavior across the ovarian cycle. Intact, postovulatory (PostOv), 
      and ovariectomized (OVX), androgen-implanted animals [OVX plus testosterone (T)] 
      exhibit male-like mounting, but not receptivity, whereas intact, preovulatory 
      (PreOv), and OVX lizards injected with estradiol [OVX plus estrogen (E)] express 
      receptivity, but not mounting. We tested whether the serotonergic system in the 
      preoptic area (POA) and ventromedial nucleus of the hypothalamus (VMN) gates the 
      reciprocal inhibition characterizing this alternating expression of mounting and 
      receptivity. Serotonergic signaling at the POA appears to be key to gating 
      male-like behavior. Postovulatory and OVX plus T animals have lower intracellular 
      serotonin (5-HT) levels, and greater abundance of inhibitory 5-HT1A receptor mRNA 
      in the POA compared with both PreOv and OVX plus E lizards. Moreover, injecting 
      5-HT into the POA of OVX plus T animals suppresses mounting, whereas injection 
      into VMN of OVX plus E lizards suppresses receptivity. Although 5-HT levels in 
      the VMN do not differ across the ovarian cycle or between hormonally manipulated 
      animals, PreOv and OVX plus E lizards have a lower abundance of 5-HT2A mRNA in 
      the VMN. Stimulating 5-HT1A receptors using systemic drug administration inhibits 
      mounting, whereas activating 5-HT2A receptors facilitates receptivity. This study 
      illuminates how male- and female-typical sexual behaviors share common neural 
      circuits, and that 5-HT regulates these naturally complementary, and mutually 
      exclusive, behaviors.
FAU - Dias, Brian George
AU  - Dias BG
AD  - Institute for Neuroscience, University of Texas at Austin, Austin, Texas 78712, 
      USA.
FAU - Crews, David
AU  - Crews D
LA  - eng
GR  - R01 MH041770/MH/NIMH NIH HHS/United States
GR  - MH41770/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20080515
PL  - United States
TA  - Endocrinology
JT  - Endocrinology
JID - 0375040
RN  - 0 (Amphetamines)
RN  - 0 (Receptor, Serotonin, 5-HT2A)
RN  - 0 (Receptor, Serotonin, 5-HT2C)
RN  - 0 (Serotonin 5-HT1 Receptor Agonists)
RN  - 0 (Serotonin 5-HT2 Receptor Agonists)
RN  - 0 (Serotonin Receptor Agonists)
RN  - 112692-38-3 (Receptor, Serotonin, 5-HT1A)
RN  - 333DO1RDJY (Serotonin)
RN  - 78950-78-4 (8-Hydroxy-2-(di-n-propylamino)tetralin)
RN  - OOM10GW9UE (4-iodo-2,5-dimethoxyphenylisopropylamine)
SB  - IM
MH  - 8-Hydroxy-2-(di-n-propylamino)tetralin/pharmacology
MH  - Amphetamines/pharmacology
MH  - Animals
MH  - Cloning, Molecular
MH  - Female
MH  - Injections, Intraventricular
MH  - Lizards/*genetics/metabolism/*physiology
MH  - Male
MH  - Ovariectomy
MH  - Parthenogenesis/drug effects/*genetics/*physiology
MH  - Preoptic Area/metabolism
MH  - Receptor, Serotonin, 5-HT1A/genetics/metabolism
MH  - Receptor, Serotonin, 5-HT2A/genetics/metabolism
MH  - Receptor, Serotonin, 5-HT2C/genetics/metabolism
MH  - Serotonin/administration & dosage/metabolism
MH  - Serotonin 5-HT1 Receptor Agonists
MH  - Serotonin 5-HT2 Receptor Agonists
MH  - Serotonin Receptor Agonists/pharmacology
MH  - Sexual Behavior, Animal/drug effects/*physiology
MH  - Ventromedial Hypothalamic Nucleus/metabolism
PMC - PMC2553382
EDAT- 2008/05/17 09:00
MHDA- 2008/10/03 09:00
PMCR- 2009/09/01
CRDT- 2008/05/17 09:00
PHST- 2008/05/17 09:00 [pubmed]
PHST- 2008/10/03 09:00 [medline]
PHST- 2008/05/17 09:00 [entrez]
PHST- 2009/09/01 00:00 [pmc-release]
AID - en.2008-0214 [pii]
AID - 4227 [pii]
AID - 10.1210/en.2008-0214 [doi]
PST - ppublish
SO  - Endocrinology. 2008 Sep;149(9):4622-31. doi: 10.1210/en.2008-0214. Epub 2008 May 
      15.