PMID- 18483395
OWN - NLM
STAT- MEDLINE
DCOM- 20080905
LR  - 20211020
IS  - 1528-0020 (Electronic)
IS  - 0006-4971 (Print)
IS  - 0006-4971 (Linking)
VI  - 112
IP  - 3
DP  - 2008 Aug 1
TI  - Cytokine storm in a mouse model of IgG-mediated hemolytic transfusion reactions.
PG  - 891-4
LID - 10.1182/blood-2008-01-132092 [doi]
AB  - Cytokines are hypothesized to play a central role in the pathophysiology of 
      IgG-mediated hemolytic transfusion reactions (HTRs), and deeper understanding is 
      required for improving therapy for these events. After establishing well-defined 
      mouse models of HTRs, we tested whether cytokines were involved. Red blood cells 
      (RBCs) from human glycophorin A transgenic (hGPA-Tg) or wild-type (WT) mice were 
      transfused into non-Tg recipients passively immunized with monoclonal antibodies 
      (Mabs). Only transfusions of incompatible RBCs induced IgG-mediated HTRs, 
      exemplified by rapid clearance and hemoglobinuria. Very high plasma levels of 
      monocyte chemoattractant protein-1 (MCP-1) and interleukin-6 (IL-6), and lower 
      levels of tumor necrosis factor-alpha (TNF-alpha), were induced after 
      incompatible transfusion. No significant changes in IL-10, IL-12, or 
      interferon-gamma (IFN-gamma) levels were observed. The proinflammatory cytokines 
      elaborated in this in vivo mouse model are also implicated in the systemic 
      inflammatory response syndrome (SIRS) and confirm the hypothesis that cytokine 
      storm occurs as a result of HTRs.
FAU - Hod, Eldad A
AU  - Hod EA
AD  - Department of Pathology and Cell Biology, Columbia University Medical Center, New 
      York, NY 10023, USA.
FAU - Cadwell, Chantel M
AU  - Cadwell CM
FAU - Liepkalns, Justine S
AU  - Liepkalns JS
FAU - Zimring, James C
AU  - Zimring JC
FAU - Sokol, Set A
AU  - Sokol SA
FAU - Schirmer, David A
AU  - Schirmer DA
FAU - Jhang, Jeffrey
AU  - Jhang J
FAU - Spitalnik, Steven L
AU  - Spitalnik SL
LA  - eng
GR  - R21 HL987906/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20080515
PL  - United States
TA  - Blood
JT  - Blood
JID - 7603509
RN  - 0 (Cytokines)
RN  - 0 (Glycophorins)
RN  - 0 (Immunoglobulin G)
SB  - IM
MH  - Animals
MH  - Blood Group Incompatibility
MH  - Cytokines/*biosynthesis
MH  - Glycophorins
MH  - Hemolysis/*immunology
MH  - Humans
MH  - Immunoglobulin G
MH  - Inflammation
MH  - Mice
MH  - Mice, Transgenic
MH  - Models, Animal
MH  - *Transfusion Reaction
PMC - PMC2481546
EDAT- 2008/05/17 09:00
MHDA- 2008/09/06 09:00
PMCR- 2009/08/01
CRDT- 2008/05/17 09:00
PHST- 2008/05/17 09:00 [pubmed]
PHST- 2008/09/06 09:00 [medline]
PHST- 2008/05/17 09:00 [entrez]
PHST- 2009/08/01 00:00 [pmc-release]
AID - S0006-4971(20)60438-4 [pii]
AID - 2008/132092 [pii]
AID - 10.1182/blood-2008-01-132092 [doi]
PST - ppublish
SO  - Blood. 2008 Aug 1;112(3):891-4. doi: 10.1182/blood-2008-01-132092. Epub 2008 May 
      15.