PMID- 18484169
OWN - NLM
STAT- MEDLINE
DCOM- 20081112
LR  - 20211203
IS  - 0271-9142 (Print)
IS  - 0271-9142 (Linking)
VI  - 28
IP  - 5
DP  - 2008 Sep
TI  - IL1 gene cluster polymorphisms and its haplotypes may predict the risk to develop 
      invasive pulmonary aspergillosis and modulate C-reactive protein level.
PG  - 473-85
LID - 10.1007/s10875-008-9197-0 [doi]
AB  - OBJECTIVE: The aim of this study was to determine whether interleukin-1 alpha 
      (IL1alpha), interleukin-1 beta (IL1beta), and IL1 receptor antagonist (IL1Ra) 
      polymorphisms are implicated in invasive pulmonary aspergillosis (IPA) 
      pathogenesis. MATERIALS AND METHODS: Subjects comprised 110 hematological 
      patients and 148 healthy controls. Genotypic and allelic frequencies were similar 
      between hematological patients and controls. IPA was diagnosed in 59 of the 110 
      patients according to consensus criteria published by the European Organization 
      for Research and Treatment of Cancer/Invasive Fungal Infections Cooperative Group 
      (EORTC/IFICG). RESULTS AND DISCUSSIONS: Individual locus analysis showed that 
      IL1alpha and IL1Ra polymorphisms were not associated with the presence of IPA (p 
      = 0.560 and p = 0.680, respectively). However, a trend towards a higher presence 
      of IL1beta( - ) (511TT) genotype (or IL1beta(-511T) allele) in the IPA group than 
      in the non-IPA patient group (p = 0.092 and p = 0.095, respectively) was found. 
      Haplotype analysis revealed that VNTR2/-889C/-511T haplotype was strongly 
      associated with susceptibility to develop IPA infection (p = 0.020). Haplotype 
      analysis also showed an association between VNTR2/-889C/-511C haplotype and 
      resistance to IPA infection (p = 0.028). Furthermore, patients with IL1Ra VNTR2/2 
      and IL1beta(-511)T/T genotypes had a higher positive serum galactomannan 
      percentage versus patients with other genotypes. Finally, C-reactive protein 
      (CRP) production was significantly associated with IL1 gene cluster 
      polymorphisms, although CRP values were similar between IPA and non-IPA groups. 
      CONCLUSION: These findings indicate a critical role of IL1 gene cluster 
      polymorphisms in the susceptibility to IPA infection and CRP production.
FAU - Sainz, J
AU  - Sainz J
AD  - Unidad de Investigacion, Hospital Universitario Virgen de las Nieves, Granada, 
      Spain. jsainz@ugr.es
FAU - Perez, E
AU  - Perez E
FAU - Gomez-Lopera, S
AU  - Gomez-Lopera S
FAU - Jurado, M
AU  - Jurado M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080517
PL  - Netherlands
TA  - J Clin Immunol
JT  - Journal of clinical immunology
JID - 8102137
RN  - 0 (Interleukin-1alpha)
RN  - 0 (Interleukin-1beta)
RN  - 0 (Mannans)
RN  - 0 (Receptors, Interleukin-1 Type I)
RN  - 11078-30-1 (galactomannan)
RN  - 9007-41-4 (C-Reactive Protein)
RN  - X2RN3Q8DNE (Galactose)
SB  - IM
MH  - Aspergillosis/blood/etiology/*genetics
MH  - Aspergillus/immunology
MH  - C-Reactive Protein/metabolism
MH  - Drug-Related Side Effects and Adverse Reactions
MH  - Female
MH  - Galactose/analogs & derivatives
MH  - Genetic Predisposition to Disease
MH  - Haplotypes
MH  - Hematologic Neoplasms/blood/complications/drug therapy
MH  - Humans
MH  - Immunocompromised Host
MH  - Interleukin-1alpha/blood/*genetics/immunology
MH  - Interleukin-1beta/blood/*genetics/immunology
MH  - Lung Diseases, Fungal/blood/etiology/*genetics
MH  - Male
MH  - Mannans/blood
MH  - Multigene Family
MH  - Polymorphism, Single Nucleotide
MH  - Receptors, Interleukin-1 Type I/blood/*genetics/immunology
MH  - Statistics as Topic
EDAT- 2008/05/20 09:00
MHDA- 2008/11/13 09:00
CRDT- 2008/05/20 09:00
PHST- 2008/01/20 00:00 [received]
PHST- 2008/03/11 00:00 [accepted]
PHST- 2008/05/20 09:00 [pubmed]
PHST- 2008/11/13 09:00 [medline]
PHST- 2008/05/20 09:00 [entrez]
AID - 10.1007/s10875-008-9197-0 [doi]
PST - ppublish
SO  - J Clin Immunol. 2008 Sep;28(5):473-85. doi: 10.1007/s10875-008-9197-0. Epub 2008 
      May 17.