PMID- 18485756
OWN - NLM
STAT- MEDLINE
DCOM- 20080814
LR  - 20211109
IS  - 1532-2165 (Electronic)
IS  - 1078-5884 (Linking)
VI  - 36
IP  - 2
DP  - 2008 Aug
TI  - Screening for abdominal aortic aneurysm reduces overall mortality in men. A 
      meta-analysis of the mid- and long-term effects of screening for abdominal aortic 
      aneurysms.
PG  - 167-171
LID - S1078-5884(08)00175-5 [pii]
LID - 10.1016/j.ejvs.2008.03.006 [doi]
AB  - BACKGROUND: Four randomised controlled trials of screening older men for 
      abdominal aortic aneurysms (AAA) have been completed. A meta-analysis was 
      performed to examine the pooled effects of screening on both mid- and long-term 
      AAA-related and total mortality, and operations for AAA. METHODS: Pooled mid-term 
      (3(1/2)-5 years) and long term (7-15 years) effects were calculated as 
      odds-ratios (ORs) with 95% confidence intervals in fixed effect models. Long-term 
      data from the West Australian trial were limited to all-caurse deaths. 
      Heterogeneity between the studies was assessed by the chi(2)-test. In cases of 
      heterogeneity, random effect models were used. RESULTS: The pooled mid-term 
      analysis showed the offer of screening caused a significant reduction in AAA 
      related mortality (OR=0.56, 95% C.I. 0.44,0.72), and emergency operations 
      (OR=0.55, 95% C.I.: 0.39; 0.76), while the number of elective operations 
      increased significantly (OR=3.27, 95% C.I.: 2.14; 5.00). Overall mortality was 
      reduced, but not significantly (OR=0.94, 95% C.I.: 0.86; 1.02). The long-term 
      results also showed a significant reduction in AAA-related mortality (OR=0.47, 
      95% C.I.: 0.25; 0.90), overall mortality (OR=0.94, 95% C.I.: 0.92; 0.97) and 
      emergency operations (OR=0.48, 95% C.I.: 0.28; 0.83), while the number of 
      elective operations increased significantly (OR=2.81, 95% C.I.: 2.40; 3.30). 
      CONCLUSION: Population screening for AAA reduces AAA-related and overall 
      mortality, however local differences may exits which could influence cost 
      effectiveness of screening.
FAU - Lindholt, J S
AU  - Lindholt JS
AD  - Vascular Research Unit, Viborg Hospital, Denmark. Electronic address: 
      jes.s.lindholt@sygehusviborg.dk.
FAU - Norman, P
AU  - Norman P
AD  - School of Surgery, University of Western Australia, Australia.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
DEP - 20080515
PL  - England
TA  - Eur J Vasc Endovasc Surg
JT  - European journal of vascular and endovascular surgery : the official journal of 
      the European Society for Vascular Surgery
JID - 9512728
SB  - IM
CIN - Eur J Vasc Endovasc Surg. 2008 Nov;36(5):620-1; author reply 621-2. PMID: 
      18774311
CIN - Eur J Vasc Endovasc Surg. 2009 Jun;37(6):739-40; author reply 740. PMID: 19346139
MH  - Aged
MH  - Aged, 80 and over
MH  - Aortic Aneurysm, Abdominal/*diagnosis/economics/*mortality/surgery
MH  - Cost-Benefit Analysis
MH  - Elective Surgical Procedures/statistics & numerical data
MH  - Emergency Treatment/statistics & numerical data
MH  - Humans
MH  - Male
MH  - *Mass Screening/economics/methods
MH  - Odds Ratio
MH  - Risk Assessment
MH  - Time Factors
MH  - Vascular Surgical Procedures/*statistics & numerical data
EDAT- 2008/05/20 09:00
MHDA- 2008/08/15 09:00
CRDT- 2008/05/20 09:00
PHST- 2007/11/11 00:00 [received]
PHST- 2008/03/06 00:00 [accepted]
PHST- 2008/05/20 09:00 [pubmed]
PHST- 2008/08/15 09:00 [medline]
PHST- 2008/05/20 09:00 [entrez]
AID - S1078-5884(08)00175-5 [pii]
AID - 10.1016/j.ejvs.2008.03.006 [doi]
PST - ppublish
SO  - Eur J Vasc Endovasc Surg. 2008 Aug;36(2):167-171. doi: 
      10.1016/j.ejvs.2008.03.006. Epub 2008 May 15.