PMID- 18485900 OWN - NLM STAT- MEDLINE DCOM- 20080725 LR - 20220330 IS - 0014-5793 (Print) IS - 1873-3468 (Electronic) IS - 0014-5793 (Linking) VI - 582 IP - 13 DP - 2008 Jun 11 TI - Autocrine motility factor stimulates the invasiveness of malignant cells as well as up-regulation of matrix metalloproteinase-3 expression via a MAPK pathway. PG - 1877-82 LID - 10.1016/j.febslet.2008.05.005 [doi] AB - The autocrine motility factor (AMF) is a multifunctional protein that is involved in tumor progression including enhanced invasiveness via induction of matrix metalloproteinase-3 (MMP3). The increase in MMP3 was found in an AMF-high production tumor cell line, and c-Jun, c-Fos and mitogen-activated protein kinases (MAPKs) were also highly phosphorylated compared with the parent line. AMF stimulation induced the rapid phosphorylation of the cellular MAPK cascade and MMP3 secretion, which was blocked using a specific MAPK inhibitor. Results of this study suggest that AMF stimulation stimulates MMP3 expression via a MAPK signaling pathway. FAU - Haga, Arayo AU - Haga A AD - Gifu Prefectural Research Institute for Health and Environmental Science, 1-1, Naka-Fudougaoka, Kakamigahara 504-0838, Japan. haga-arayo@pref.gifu.lg.jp FAU - Funasaka, Tatsuyoshi AU - Funasaka T FAU - Deyashiki, Yoshihiro AU - Deyashiki Y FAU - Raz, Avraham AU - Raz A LA - eng GR - R01 CA051714/CA/NCI NIH HHS/United States PT - Journal Article DEP - 20080515 PL - England TA - FEBS Lett JT - FEBS letters JID - 0155157 RN - 0 (Proto-Oncogene Proteins c-fos) RN - 0 (Receptors, Cytokine) RN - EC 2.3.2.27 (AMFR protein, human) RN - EC 2.3.2.27 (Receptors, Autocrine Motility Factor) RN - EC 2.3.2.27 (Ubiquitin-Protein Ligases) RN - EC 2.7.11.24 (Mitogen-Activated Protein Kinases) RN - EC 2.7.12.2 (MAP Kinase Kinase 4) RN - EC 3.4.24.17 (Matrix Metalloproteinase 3) RN - EC 5.3.1.9 (Glucose-6-Phosphate Isomerase) SB - IM MH - Cell Line, Tumor MH - Cell Movement MH - Enzyme Activation MH - Glucose-6-Phosphate Isomerase/*metabolism/pharmacology MH - Humans MH - MAP Kinase Kinase 4/antagonists & inhibitors/*metabolism MH - Matrix Metalloproteinase 3/genetics/*metabolism MH - Mitogen-Activated Protein Kinases/metabolism MH - *Neoplasm Invasiveness MH - Phosphorylation MH - Proto-Oncogene Proteins c-fos/metabolism MH - Receptors, Autocrine Motility Factor MH - Receptors, Cytokine/genetics/metabolism MH - Ubiquitin-Protein Ligases/genetics/metabolism MH - Up-Regulation PMC - PMC3788612 MID - NIHMS515357 EDAT- 2008/05/20 09:00 MHDA- 2008/07/26 09:00 PMCR- 2013/10/02 CRDT- 2008/05/20 09:00 PHST- 2008/02/26 00:00 [received] PHST- 2008/04/16 00:00 [revised] PHST- 2008/05/06 00:00 [accepted] PHST- 2008/05/20 09:00 [pubmed] PHST- 2008/07/26 09:00 [medline] PHST- 2008/05/20 09:00 [entrez] PHST- 2013/10/02 00:00 [pmc-release] AID - S0014-5793(08)00402-X [pii] AID - 10.1016/j.febslet.2008.05.005 [doi] PST - ppublish SO - FEBS Lett. 2008 Jun 11;582(13):1877-82. doi: 10.1016/j.febslet.2008.05.005. Epub 2008 May 15.