PMID- 18487068
OWN - NLM
STAT- MEDLINE
DCOM- 20090205
LR  - 20200205
IS  - 1778-7254 (Electronic)
IS  - 1297-319X (Linking)
VI  - 75
IP  - 5
DP  - 2008 Oct
TI  - No differences of carotid intima-media thickness between young patients with 
      ankylosing spondylitis and healthy controls.
PG  - 548-53
LID - 10.1016/j.jbspin.2007.11.007 [doi]
AB  - OBJECTIVE: Accelerated atherosclerosis in inflammatory rheumatic diseases such as 
      ankylosing spondylitis (AS) stands out among the leading causes of morbidity and 
      mortality. We assessed the correlation between subclinical carotid 
      atherosclerosis and its related clinical parameters in AS patients. METHODS: 
      Twenty-eight patients (23 males, 5 females) with AS and 27 sex- and age-matched 
      controls were consecutively recruited to this study. We estimated the carotid 
      intima-media thickness (IMT) and parameters related to arterial elastic 
      properties, including the distensibility coefficient (DC), stiffness index 
      (beta), and incremental elastic modulus (E(inc)) using high-resolution 
      ultrasonography. Serum levels of tumor necrosis factor-alpha (TNF-alpha), 
      interleukin-6 (IL-6), and monocyte chemoattractant protein-1 (MCP-1) were 
      measured using enzyme-linked immunosorbent assay (ELISA). RESULTS: Carotid IMT 
      values and arterial elastic parameters in AS patients showed no statistical 
      significance compared to those of controls (0.57+/-0.07 vs 0.55+/-0.05, p=0.387 
      for IMT, 28.45+/-9.23 vs 31.93+/-9.52, p=0.175 for DC, 2.32+/-0.18 vs 
      2.29+/-0.15, p=0.559 for stiffness index (beta), and 0.14+/-0.05 vs 0.12+/-0.03, 
      p=0.116 for E(inc)). The serum level of IL-6 in AS patients was significantly 
      different compared with controls (p=0.001), but not in serum levels of TNF-alpha 
      and MCP-1 (p=0.162, p=0.087, respectively). Carotid IMT and all arterial elastic 
      parameters calculated in this study were not found to be associated with serum 
      levels of TNF-alpha, IL-6, and MCP-1. CONCLUSION: This cross-sectional study 
      showed that carotid IMT and parameters related with arterial elastic properties 
      in young AS patients without clinically evident cardiovascular risk factors were 
      not different from those of sex- and age-matched healthy controls. Serum levels 
      of TNF-alpha, IL-6, and MCP-1 did not reflect the degree of carotid subclinical 
      atherosclerosis. However, these findings should be confirmed further in a larger 
      population.
FAU - Choe, Jung-Yoon
AU  - Choe JY
AD  - Department of Internal Medicine, Catholic University of Daegu School of Medicine, 
      3056-6 Daemyung 4-Dong, Nam-Gu, Daegu 705-718, Republic of Korea.
FAU - Lee, Myoung-Yong
AU  - Lee MY
FAU - Rheem, Insoo
AU  - Rheem I
FAU - Rhee, Moo-Yong
AU  - Rhee MY
FAU - Park, Sung-Hoon
AU  - Park SH
FAU - Kim, Seong-Kyu
AU  - Kim SK
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20080519
PL  - France
TA  - Joint Bone Spine
JT  - Joint bone spine
JID - 100938016
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Interleukin-6)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Adult
MH  - Atherosclerosis/blood/etiology/pathology/physiopathology
MH  - Carotid Arteries/diagnostic imaging/*pathology/physiopathology
MH  - Chemokine CCL2/blood
MH  - Cross-Sectional Studies
MH  - Elastic Modulus/physiology
MH  - Female
MH  - Humans
MH  - Interleukin-6/blood
MH  - Male
MH  - Spondylitis, Ankylosing/blood/complications/*pathology/physiopathology
MH  - Tumor Necrosis Factor-alpha/blood
MH  - Tunica Intima/diagnostic imaging/*pathology/physiopathology
MH  - Tunica Media/diagnostic imaging/*pathology/physiopathology
MH  - Ultrasonography
EDAT- 2008/05/20 09:00
MHDA- 2009/02/06 09:00
CRDT- 2008/05/20 09:00
PHST- 2007/09/08 00:00 [received]
PHST- 2007/11/21 00:00 [accepted]
PHST- 2008/05/20 09:00 [pubmed]
PHST- 2009/02/06 09:00 [medline]
PHST- 2008/05/20 09:00 [entrez]
AID - S1297-319X(08)00099-7 [pii]
AID - 10.1016/j.jbspin.2007.11.007 [doi]
PST - ppublish
SO  - Joint Bone Spine. 2008 Oct;75(5):548-53. doi: 10.1016/j.jbspin.2007.11.007. Epub 
      2008 May 19.