PMID- 18487481
OWN - NLM
STAT- MEDLINE
DCOM- 20080820
LR  - 20211020
IS  - 1935-5548 (Electronic)
IS  - 0149-5992 (Print)
IS  - 0149-5992 (Linking)
VI  - 31
IP  - 8
DP  - 2008 Aug
TI  - Increased risk of diabetes and polychlorinated biphenyls and dioxins: a 24-year 
      follow-up study of the Yucheng cohort.
PG  - 1574-9
LID - 10.2337/dc07-2449 [doi]
AB  - OBJECTIVE: Polychlorinated biphenyls (PCBs) and polychlorinated dibenzofurans 
      (PCDFs) are important and persistent organic pollutants (POPs) in humans. Recent 
      cross-sectional studies have detected increased concentrations of serum POPs in 
      diabetic patients. We aimed to examine the association between previous high 
      exposures to PCBs and PCDFs and the cumulative incidence of type 2 diabetes and 
      hypertension. RESEARCH DESIGN AND METHODS: During the late 1970s, the consumption 
      of rice-bran oil laced with PCBs poisoned thousands of Taiwanese. Between 1993 
      and 2003, we examined 1,054 Yucheng ("oil disease") victims against neighborhood 
      reference subjects using a protocol blinded for POP exposure. Here, we report the 
      results derived from 378 Yucheng subjects and 370 matched references. RESULTS: 
      The diabetes risk to members of the Yucheng cohort relative to their reference 
      subjects was significantly increased for women (odds ratio [OR] 2.1 [95% CI 
      1.1-4.5]) but not for men after considering age, BMI, cigarette smoking, and 
      alcohol intake. Yucheng women diagnosed with chloracne had adjusted ORs of 5.5 
      (95% CI 2.3-13.4) for diabetes and 3.5 (1.7-7.2) for hypertension compared with 
      those who were chloracne free. CONCLUSIONS: Yucheng women, who had endured 
      previous exposure to PCBs and PCDFs, suffered from increased incidences of 
      diabetes, particularly those who had retained significant levels of pollutant as 
      evident from chloracne. When planning treatments against diabetes, the body 
      burden of PCBs and dioxins should be carefully considered, especially for women.
FAU - Wang, Shu-Li
AU  - Wang SL
AD  - Division of Environmental Health and Occupational Medicine, National Health 
      Research Institutes, Miaoli, Taiwan.
FAU - Tsai, Pei-Chien
AU  - Tsai PC
FAU - Yang, Chiu-Yueh
AU  - Yang CY
FAU - Guo, Yueliang Leon
AU  - Guo YL
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080516
PL  - United States
TA  - Diabetes Care
JT  - Diabetes care
JID - 7805975
RN  - 0 (Air Pollutants)
RN  - 0 (Dioxins)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Air Pollutants
MH  - Diabetes Mellitus/*epidemiology
MH  - *Dioxins/blood
MH  - *Environmental Exposure
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Incidence
MH  - Male
MH  - Middle Aged
MH  - Odds Ratio
MH  - *Polychlorinated Biphenyls/blood
MH  - Registries
MH  - Risk Factors
MH  - Taiwan/epidemiology
PMC - PMC2494618
EDAT- 2008/05/20 09:00
MHDA- 2008/08/21 09:00
PMCR- 2009/08/01
CRDT- 2008/05/20 09:00
PHST- 2008/05/20 09:00 [pubmed]
PHST- 2008/08/21 09:00 [medline]
PHST- 2008/05/20 09:00 [entrez]
PHST- 2009/08/01 00:00 [pmc-release]
AID - dc07-2449 [pii]
AID - 3181574 [pii]
AID - 10.2337/dc07-2449 [doi]
PST - ppublish
SO  - Diabetes Care. 2008 Aug;31(8):1574-9. doi: 10.2337/dc07-2449. Epub 2008 May 16.