PMID- 18487493
OWN - NLM
STAT- MEDLINE
DCOM- 20080905
LR  - 20120607
IS  - 0300-9858 (Print)
IS  - 0300-9858 (Linking)
VI  - 45
IP  - 3
DP  - 2008 May
TI  - Expression of brain-derived neurotrophic factor and tropomyosin-related kinase-B 
      in a bovine jejunal nodular ganglioneuroblastoma.
PG  - 355-60
LID - 10.1354/vp.45-3-355 [doi]
AB  - This report describes the morphologic, ultrastructural, and immunophenotypic 
      features of a nodular ganglioneuroblastoma in the jejunum of a 13-month-old 
      Holstein-Friesian heifer. On histologic examination, the mass was composed of 
      clusters of neuroblasts and isolated ganglionic neurons in abundant neurophilic 
      matrix that was surrounded by scanty Schwannian stroma. On ultrastructure 
      examination, the large ganglionic neuron-like cells had unmyelinated neurites. 
      Most ganglionic neuron-like tumor cells expressed neurofilament, neuron-specific 
      enolase, chromogranin A, and S-100, whereas the Schwann-cell-like stromal cells 
      expressed S-100 and vimentin. Both brain-derived neurotrophic factor (BDNF) and 
      tropomyosin-related kinase-B (Trk-B) were expressed in ganglionic neuron-like 
      tumor cells, which suggested the activation or reactivation of an embryonic 
      autocrine BDNF/Trk-B pathway that could have prolonged cell survival and promoted 
      differentiation with neurite formation.
FAU - Ulrich, R
AU  - Ulrich R
AD  - Department of Pathology, University of Veterinary Medicine Hannover, Hannover, 
      Germany.
FAU - Stan, A C
AU  - Stan AC
FAU - Koch, A
AU  - Koch A
FAU - Beineke, A
AU  - Beineke A
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Vet Pathol
JT  - Veterinary pathology
JID - 0312020
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Nerve Tissue Proteins)
RN  - EC 2.7.- (Protein Kinases)
RN  - EC 2.7.11.28 (tropomyosin kinase)
RN  - EC 2.7.11.28 (tropomyosin-related kinase-B, bovine)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*analysis
MH  - Cattle
MH  - Cattle Diseases/*enzymology
MH  - Female
MH  - Ganglioneuroblastoma/enzymology/*veterinary
MH  - Jejunal Neoplasms/pathology/*veterinary
MH  - Jejunum/pathology
MH  - Nerve Tissue Proteins/*metabolism
MH  - Protein Kinases/*metabolism
EDAT- 2008/05/20 09:00
MHDA- 2008/09/06 09:00
CRDT- 2008/05/20 09:00
PHST- 2008/05/20 09:00 [pubmed]
PHST- 2008/09/06 09:00 [medline]
PHST- 2008/05/20 09:00 [entrez]
AID - 45/3/355 [pii]
AID - 10.1354/vp.45-3-355 [doi]
PST - ppublish
SO  - Vet Pathol. 2008 May;45(3):355-60. doi: 10.1354/vp.45-3-355.