PMID- 18489265
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20100609
LR  - 20080520
IS  - 1468-2494 (Electronic)
IS  - 0142-5463 (Linking)
VI  - 28
IP  - 4
DP  - 2006 Aug
TI  - Expression and function of neurotrophins and their receptors in human 
      melanocytes.
PG  - 255-61
LID - 10.1111/j.1467-2494.2006.00321.x [doi]
AB  - Melanocytes and cells of the nervous system are of common ectodermal origin and 
      neurotrophins (NT) have been shown to be released by human keratinocytes. We 
      investigated the expression and function of NT [nerve growth factor (NGF), 
      brain-derived neurotrophic factor (BDNF), NT-3, NT-4/-5] and their receptors in 
      human melanocytes. Human melanocytes produce all NT in different amounts, whereas 
      they only release NT-4. NT-4 release is downregulated, whereas NT-3 is 
      upregulated by ultraviolet (UVB) irradiation. Melanocytes treated with phorbol 
      12-myristate 13-acetate (PMA) express TrkA and TrkB, but not TrkC. NT fail to 
      stimulate melanocyte proliferation, whereas they stimulate the synthesis of 
      tyrosinase and tyrosinase-related protein-1 (TRP-1). Finally, NT-3, NT-4 and NGF 
      increase melanin production. Taken together, these results demonstrate an 
      intriguing interaction between melanocytes and the nervous system. We speculate 
      that NT could be considered the target of therapy for disorders of skin 
      pigmentation.
FAU - Marconi, A
AU  - Marconi A
AD  - Institute of Dermatology and Plastic Surgery, University of Modena and Reggio 
      Emilia, Modena, Italy.
FAU - Panza, M C
AU  - Panza MC
FAU - Bonnet-Duquennoy, M
AU  - Bonnet-Duquennoy M
FAU - Lazou, K
AU  - Lazou K
FAU - Kurfurst, R
AU  - Kurfurst R
FAU - Truzzi, F
AU  - Truzzi F
FAU - Lotti, R
AU  - Lotti R
FAU - De Santis, G
AU  - De Santis G
FAU - Dumas, M
AU  - Dumas M
FAU - Bonte, F
AU  - Bonte F
FAU - Pincelli, C
AU  - Pincelli C
LA  - eng
PT  - Journal Article
PL  - England
TA  - Int J Cosmet Sci
JT  - International journal of cosmetic science
JID - 8007161
EDAT- 2008/05/21 09:00
MHDA- 2008/05/21 09:01
CRDT- 2008/05/21 09:00
PHST- 2008/05/21 09:00 [pubmed]
PHST- 2008/05/21 09:01 [medline]
PHST- 2008/05/21 09:00 [entrez]
AID - ICS321 [pii]
AID - 10.1111/j.1467-2494.2006.00321.x [doi]
PST - ppublish
SO  - Int J Cosmet Sci. 2006 Aug;28(4):255-61. doi: 10.1111/j.1467-2494.2006.00321.x.