PMID- 18490308
OWN - NLM
STAT- MEDLINE
DCOM- 20080814
LR  - 20081121
IS  - 1532-2114 (Electronic)
IS  - 1532-2114 (Linking)
VI  - 9
IP  - 4
DP  - 2008 Jul
TI  - Age dependency in the timing of mitral annular motion in relation to ventricular 
      filling in healthy subjects: Umea General Population Heart Study.
PG  - 522-9
LID - 10.1093/ejechocard/jen124 [doi]
AB  - AIMS: Peak left ventricular (LV) relaxation normally precedes peak filling (E), 
      which supports the hypothesis that LV suction contributes to early-diastolic 
      filling. The significance of similar temporal discordance in late diastole has 
      previously not been studied. We describe the time relationships between mitral 
      annular motion and LV filling in early and late diastole and examine the effect 
      of normal ageing on these time intervals. METHODS AND RESULTS: A total of 128 
      healthy subjects aged 25-88 years were studied. Transmitral and pulmonary venous 
      flow reversals (Ar) were recorded by Doppler echocardiography. Mitral annular 
      diastolic displacement-early (E(m)) and late (A(m))-were recorded by Doppler 
      tissue imaging. With reference to electrocardiographic R and P-waves, the 
      following measurements were made: R to peak E-wave (R-E) and E(m) (R-E(m)); onset 
      P to peak A-wave (P-pA), A(m) (P-pA(m)), and Ar (P-pAr). The differences between 
      [(R-E) and (R-E(m))] for early-diastolic temporal discordance (EDTD) and [(P-A) 
      and (P-A(m))] for late-diastolic temporal discordance (LDTD) were calculated. 
      Isovolumic relaxation time (IVRT) was also measured. Early-diastolic temporal 
      discordance was approximately 26 ms in all age groups. Late-diastolic temporal 
      discordance, however, was inversely related to age (r = -0.35, P < 0.001) and 
      IVRT (r = -0.34, P < 0.001) and therefore decreased in the elderly vs. young (13 
      +/- 10 vs. 23 +/- 10 ms; P < 0.001). In multivariate analysis, age failed to 
      predict LDTD in the presence of IVRT. A, A(m), and Ar were simultaneous at onset, 
      and peak A(m) coincided with peak Ar in all age groups (r = 0.97, P < 0.001). No 
      significant differences were noted in the RR intervals. CONCLUSIONS: Sequential 
      prolongation of IVRT with ageing reduces LDTD, thus converging the peaks of A(m), 
      A, and Ar (atrial mechanical alignment)-a potential novel method to identify 
      subjects at increased dependency on atrial contraction for late-diastolic 
      filling.
FAU - Bukachi, F
AU  - Bukachi F
AD  - Department of Medical Physiology, College of Health Sciences, Nairobi, Kenya.
FAU - Waldenstrom, A
AU  - Waldenstrom A
FAU - Morner, S
AU  - Morner S
FAU - Lindqvist, P
AU  - Lindqvist P
FAU - Henein, M Y
AU  - Henein MY
FAU - Kazzam, E
AU  - Kazzam E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080314
PL  - England
TA  - Eur J Echocardiogr
JT  - European journal of echocardiography : the journal of the Working Group on 
      Echocardiography of the European Society of Cardiology
JID - 100890618
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Aged, 80 and over
MH  - Aging
MH  - Diastole/*physiology
MH  - Echocardiography, Doppler
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Mitral Valve/*physiology/*ultrastructure
MH  - Time Factors
MH  - Ventricular Function
MH  - Ventricular Function, Left/*physiology
EDAT- 2008/05/21 09:00
MHDA- 2008/08/15 09:00
CRDT- 2008/05/21 09:00
PHST- 2008/05/21 09:00 [pubmed]
PHST- 2008/08/15 09:00 [medline]
PHST- 2008/05/21 09:00 [entrez]
AID - jen124 [pii]
AID - 10.1093/ejechocard/jen124 [doi]
PST - ppublish
SO  - Eur J Echocardiogr. 2008 Jul;9(4):522-9. doi: 10.1093/ejechocard/jen124. Epub 
      2008 Mar 14.