PMID- 18493257
OWN - NLM
STAT- MEDLINE
DCOM- 20081006
LR  - 20080825
IS  - 1559-7016 (Electronic)
IS  - 0271-678X (Linking)
VI  - 28
IP  - 9
DP  - 2008 Sep
TI  - Suppression of stroke-induced progenitor proliferation in adult subventricular 
      zone by tumor necrosis factor receptor 1.
PG  - 1574-87
LID - 10.1038/jcbfm.2008.47 [doi]
AB  - Stroke induced by middle cerebral artery occlusion leads to transiently increased 
      progenitor proliferation in the subventricular zone (SVZ) and long-lasting 
      striatal neurogenesis in adult rodents. Tumor necrosis factor-alpha (TNF-alpha) 
      is upregulated in stroke-damaged brain. Whether TNF-alpha and its receptors 
      influence SVZ progenitor proliferation after stroke is unclear. Here we show that 
      the increased proliferation 1 week after stroke occurred concomitantly with 
      elevated microglia numbers and TNF-alpha and TNF receptor-1 (TNF-R1) gene 
      expression in the SVZ of wild-type mice. TNF receptor-1 was expressed on sorted 
      SVZ progenitor cells from nestin-green fluorescent protein reporter mice. In 
      animals lacking TNF-R1, stroke-induced SVZ cell proliferation and neuroblast 
      formation were enhanced. In contrast, deletion of TNF-R1 did not alter basal or 
      status epilepticus-stimulated cell proliferation in SVZ. Addition of TNF-alpha 
      reduced the size and numbers of SVZ neurospheres through a TNF-R1-dependent 
      mechanism without affecting cell survival. Our results provide the first evidence 
      that TNF-R1 is a negative regulator of stroke-induced SVZ progenitor 
      proliferation. Blockade of TNF-R1 signaling might be a novel strategy to promote 
      the proliferative response in SVZ after stroke.
FAU - Iosif, Robert E
AU  - Iosif RE
AD  - Laboratory of Neurogenesis and Cell Therapy, Section of Restorative Neurology, 
      Wallenberg Neuroscience Center, University Hospital, Lund, Sweden.
FAU - Ahlenius, Henrik
AU  - Ahlenius H
FAU - Ekdahl, Christine T
AU  - Ekdahl CT
FAU - Darsalia, Vladimer
AU  - Darsalia V
FAU - Thored, Par
AU  - Thored P
FAU - Jovinge, Stefan
AU  - Jovinge S
FAU - Kokaia, Zaal
AU  - Kokaia Z
FAU - Lindvall, Olle
AU  - Lindvall O
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080521
PL  - United States
TA  - J Cereb Blood Flow Metab
JT  - Journal of cerebral blood flow and metabolism : official journal of the 
      International Society of Cerebral Blood Flow and Metabolism
JID - 8112566
RN  - 0 (Receptors, Tumor Necrosis Factor, Type I)
RN  - 0 (Tnfrsf1a protein, mouse)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Animals
MH  - *Cell Proliferation
MH  - Cell Survival
MH  - Infarction, Middle Cerebral Artery
MH  - Lateral Ventricles
MH  - Mice
MH  - Mice, Knockout
MH  - Receptors, Tumor Necrosis Factor, Type I/*physiology
MH  - Stem Cells/*cytology
MH  - Stroke/*pathology
MH  - Tumor Necrosis Factor-alpha/*physiology
EDAT- 2008/05/22 09:00
MHDA- 2008/10/07 09:00
CRDT- 2008/05/22 09:00
PHST- 2008/05/22 09:00 [pubmed]
PHST- 2008/10/07 09:00 [medline]
PHST- 2008/05/22 09:00 [entrez]
AID - jcbfm200847 [pii]
AID - 10.1038/jcbfm.2008.47 [doi]
PST - ppublish
SO  - J Cereb Blood Flow Metab. 2008 Sep;28(9):1574-87. doi: 10.1038/jcbfm.2008.47. 
      Epub 2008 May 21.