PMID- 18493767
OWN - NLM
STAT- MEDLINE
DCOM- 20090424
LR  - 20221207
IS  - 0172-8172 (Print)
IS  - 0172-8172 (Linking)
VI  - 29
IP  - 1
DP  - 2008 Nov
TI  - Human leukocyte antigen-B*2705 is the predominant subtype in the Korean 
      population with ankylosing spondylitis, unlike in other Asians.
PG  - 43-6
LID - 10.1007/s00296-008-0602-z [doi]
AB  - This study was performed to investigate the frequency of human leukocyte antigen 
      (HLA)-B27 subtypes in the Korean population with spondyloarthropathy (SpA). We 
      determined the HLA subtypes of 267 SpA patients who were positive for the B27 
      antigen (as determined by serology) by using a PEL-FREEZ kit (Dynal Biotech, 
      Wisconsin, USA). Clinical features, including sex, peripheral joint involvement, 
      and the presence of uveitis, were analyzed in a retrospective cohort study. Among 
      267 patients, 244 were B*2705-positive and 22 were B*2704-positive. One patient 
      was positive for B*2704/2705. No other subtype was observed among the analyzed 
      patients. We found that HLA-B*2705 was the predominant subtype in Koreans with 
      SpA; this finding is remarkable because other Asians such as the Han or the 
      Japanese exclusively have the B*2704 subtype. This result suggests that the 
      clinical features and prevalence of SpA in Koreans may be similar to those 
      observed in Europeans.
FAU - Lee, Sang-Hoon
AU  - Lee SH
AD  - Department of Rheumatology, College of Medicine, Kyung Hee University, 1 
      Hoegi-dong, Dongdaemun-gu, Seoul, South Korea.
FAU - Choi, In-Ah
AU  - Choi IA
FAU - Lee, Yeon-Ah
AU  - Lee YA
FAU - Park, Eun-Kyung
AU  - Park EK
FAU - Kim, Young-Hoon
AU  - Kim YH
FAU - Kim, Kyoung-Soo
AU  - Kim KS
FAU - Hong, Seung-Jae
AU  - Hong SJ
FAU - Yoo, Myung Chul
AU  - Yoo MC
FAU - Yang, Hyung-In
AU  - Yang HI
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080521
PL  - Germany
TA  - Rheumatol Int
JT  - Rheumatology international
JID - 8206885
RN  - 0 (HLA-B27 Antigen)
SB  - IM
MH  - Adult
MH  - *Asian People
MH  - Cross-Sectional Studies
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - HLA-B27 Antigen/blood/*genetics/immunology
MH  - Humans
MH  - Korea/epidemiology
MH  - Male
MH  - Polymorphism, Genetic/*genetics
MH  - Spondylitis, Ankylosing/ethnology/*genetics/immunology
MH  - Young Adult
EDAT- 2008/05/22 09:00
MHDA- 2009/04/25 09:00
CRDT- 2008/05/22 09:00
PHST- 2008/01/22 00:00 [received]
PHST- 2008/05/04 00:00 [accepted]
PHST- 2008/05/22 09:00 [pubmed]
PHST- 2009/04/25 09:00 [medline]
PHST- 2008/05/22 09:00 [entrez]
AID - 10.1007/s00296-008-0602-z [doi]
PST - ppublish
SO  - Rheumatol Int. 2008 Nov;29(1):43-6. doi: 10.1007/s00296-008-0602-z. Epub 2008 May 
      21.