PMID- 1849437
OWN - NLM
STAT- MEDLINE
DCOM- 19910516
LR  - 20190613
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 538
IP  - 2
DP  - 1991 Jan 11
TI  - Grooming induced by intrahypothalamic injection of ACTH in the rat: comparison 
      with grooming induced by intrahypothalamic electrical stimulation and i.c.v. 
      injection of ACTH.
PG  - 203-10
AB  - Intracerebroventricular (i.c.v.) injection of adrenocorticotropic hormone (ACTH) 
      elicits grooming in the rat, but the neural organization of this response is 
      still obscure. Electrical stimulation (EHS) in an area around the hypothalamic 
      paraventricular nucleus (PVH) also elicits grooming. This hypothalamic area 
      contains many ACTH-immunoreactive fibres. Injection of ACTH1-24 (0.3 
      microgram/0.3 microliters) in the same area elicits intense grooming responses in 
      the rat. Latency, intensity and precise patterning of the grooming response are 
      dependent upon the exact site of injection. Comparison of grooming responses 
      elicited by EHS, ACTH injected i.c.v. and ACTH injected in the PVH reveals that 
      these are slightly dissimilar. This may provide clues as to the brain mechanisms 
      involved in the organization of the different components of grooming. EHS does 
      not elicits scratching and even reduces 'spontaneous' scratching. Also, 
      EHS-elicited grooming is characterized by short pauses. The time-course of 
      appearance of yawning differs between ACTH-PVH and ACTH-i.c.v. injections. 
      Excited locomotion elicited only by ACTH-i.c.v. is apparently caused by 
      ACTH-sensitive systems outside the PVH. The results suggest that the 
      ACTH-containing part of the hypothalamus around the PVH is crucially involved in 
      the organization of grooming behaviour. We believe that at this level in the 
      brain, the subroutines of grooming, scratching and yawning are integrated into 
      one skin maintenance behaviour.
FAU - Van Erp, A M
AU  - Van Erp AM
AD  - Ethopharmacology Group, Sylvius Laboratory, Leiden, The Netherlands.
FAU - Kruk, M R
AU  - Kruk MR
FAU - Willekens-Bramer, D C
AU  - Willekens-Bramer DC
FAU - Bressers, W M
AU  - Bressers WM
FAU - Roeling, T A
AU  - Roeling TA
FAU - Veening, J G
AU  - Veening JG
FAU - Spruyt, B M
AU  - Spruyt BM
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 16960-16-0 (Cosyntropin)
RN  - 9002-60-2 (Adrenocorticotropic Hormone)
SB  - IM
MH  - Adrenocorticotropic Hormone/administration & dosage/*pharmacology
MH  - Animals
MH  - Cosyntropin/pharmacology
MH  - Electric Stimulation
MH  - Grooming/*drug effects/physiology
MH  - Hypothalamus/anatomy & histology/*physiology
MH  - Injections
MH  - Injections, Intraventricular
MH  - Male
MH  - Motor Activity/drug effects
MH  - Paraventricular Hypothalamic Nucleus/anatomy & histology/physiology
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Yawning/drug effects
EDAT- 1991/01/11 00:00
MHDA- 1991/01/11 00:01
CRDT- 1991/01/11 00:00
PHST- 1991/01/11 00:00 [pubmed]
PHST- 1991/01/11 00:01 [medline]
PHST- 1991/01/11 00:00 [entrez]
AID - 0006-8993(91)90431-T [pii]
AID - 10.1016/0006-8993(91)90431-t [doi]
PST - ppublish
SO  - Brain Res. 1991 Jan 11;538(2):203-10. doi: 10.1016/0006-8993(91)90431-t.