PMID- 18495421
OWN - NLM
STAT- MEDLINE
DCOM- 20081216
LR  - 20191210
IS  - 0892-0362 (Print)
IS  - 0892-0362 (Linking)
VI  - 30
IP  - 5
DP  - 2008 Sep-Oct
TI  - Gestational all-trans retinoic acid treatment in the rat: neurofunctional changes 
      and cerebellar phenotype.
PG  - 395-403
LID - 10.1016/j.ntt.2008.03.064 [doi]
AB  - Neurofunctional effects produced by gestational all-trans retinoic acid 
      (all-trans RA) treatment were investigated in the offspring of Sprague-Dawley 
      rats. Reproduction data, onset of reflexive behavior, locomotor activity, motor 
      coordination and motor learning were examined. Moreover, possible changes in size 
      and morphology of the cerebellum were evaluated. The results show that all-trans 
      RA treatment (2.5 mg/kg, by gavage) on gestational days (GD) 11-13 significantly 
      increased postnatal mortality and decreased pup weight gain. Moreover, all-trans 
      RA-treated rats showed a significant delay in eyes opening, hair growth as well 
      as in the maturation of righting reflex, cliff aversion and pole grasping. 
      All-trans RA treatment significantly impaired the ambulatory activity in adult 
      rats without altering the number of rearings. All-trans RA-treated rats subjected 
      to the rotarod/accelerod task showed significant impairment in both motor 
      coordination and motor learning ability. The morphological analysis revealed a 
      significant reduction in the cerebellar size and impairment in foliation profile, 
      at PND 3 with subsequent recovery at PNDs 8 and 40. The evidence that functional 
      alterations increase with age and persist in adulthood whereas the morphological 
      changes decline with age, strongly supports the view that, besides the cerebellum 
      morphology, the organization of the cerebellar circuitry, and in particular of 
      cortico-cerebellar connections, are also affected by all-trans RA treatment.
FAU - Coluccia, Addolorata
AU  - Coluccia A
AD  - Department of Pharmacology and Human Physiology, Medical School, University of 
      Bari, Policlinico, Piazza Giulio Cesare 11, 70124 Bari, Italy.
FAU - Belfiore, Domenico
AU  - Belfiore D
FAU - Bizzoca, Antonella
AU  - Bizzoca A
FAU - Borracci, Pietro
AU  - Borracci P
FAU - Trerotoli, Paolo
AU  - Trerotoli P
FAU - Gennarini, Gianfranco
AU  - Gennarini G
FAU - Carratu, Maria Rosaria
AU  - Carratu MR
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080401
PL  - United States
TA  - Neurotoxicol Teratol
JT  - Neurotoxicology and teratology
JID - 8709538
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Teratogens)
RN  - 5688UTC01R (Tretinoin)
SB  - IM
MH  - Administration, Oral
MH  - Animals
MH  - Antineoplastic Agents/toxicity
MH  - Body Weight/drug effects
MH  - Cerebellum/*abnormalities/*drug effects/pathology
MH  - Dyskinesia, Drug-Induced/physiopathology
MH  - Female
MH  - Learning Disabilities/chemically induced/physiopathology
MH  - Male
MH  - Motor Activity/drug effects
MH  - Motor Skills Disorders/chemically induced/physiopathology
MH  - Nervous System Malformations/*chemically induced/pathology/physiopathology
MH  - Neural Pathways/abnormalities/drug effects/physiopathology
MH  - Phenotype
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects/pathology/*physiopathology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Reproduction/drug effects
MH  - Sex Characteristics
MH  - Stereoisomerism
MH  - Teratogens/*toxicity
MH  - Time
MH  - Tretinoin/*toxicity
EDAT- 2008/05/23 09:00
MHDA- 2008/12/17 09:00
CRDT- 2008/05/23 09:00
PHST- 2007/07/19 00:00 [received]
PHST- 2008/02/25 00:00 [revised]
PHST- 2008/03/19 00:00 [accepted]
PHST- 2008/05/23 09:00 [pubmed]
PHST- 2008/12/17 09:00 [medline]
PHST- 2008/05/23 09:00 [entrez]
AID - S0892-0362(08)00105-0 [pii]
AID - 10.1016/j.ntt.2008.03.064 [doi]
PST - ppublish
SO  - Neurotoxicol Teratol. 2008 Sep-Oct;30(5):395-403. doi: 10.1016/j.ntt.2008.03.064. 
      Epub 2008 Apr 1.