PMID- 18495743
OWN - NLM
STAT- MEDLINE
DCOM- 20090302
LR  - 20151119
IS  - 1460-2385 (Electronic)
IS  - 0931-0509 (Linking)
VI  - 23
IP  - 11
DP  - 2008 Nov
TI  - Glomerular expression of monocyte chemoattractant protein-1 is predictive of poor 
      renal prognosis in pediatric lupus nephritis.
PG  - 3521-6
LID - 10.1093/ndt/gfn270 [doi]
AB  - BACKGROUND: Monocyte chemoattractant protein-1 (MCP-1) is upregulated and it 
      recruits and activates inflammatory cells in murine lupus nephritis (LN). 
      METHODS: Clinical outcomes of children with LN were examined in relation to 
      glomerular expression of MCP-1 and macrophage infiltration, as determined by 
      immunohistochemical staining of renal biopsy sections with MCP-1 and CD68. 
      Sections were analysed using a modified histological score (H-score; maximum of 
      300) based on both percentage of positively stained cells and intensity of 
      staining. RESULTS: Renal biopsies were examined from 34 children [27 (79%) 
      female] aged 7.7-17.3 (median 13.7) years with 50% ISN/RPS Class IV LN. Renal 
      dysfunction and proteinuria at follow-up of 2.2-15.4 (median 6.5) years were 
      analysed with estimated glomerular filtration rates (eGFR) of 11.2-124.1 (median 
      93.6) ml/min/1.73 m(2) and urine albumin:creatinine ratios of 1-535 (median 63) 
      mg/mmol. There was a correlation between glomerular expression of MCP-1 and CD68 
      (r = 0.98, P = 0.04; median modified H-score of 219.7 and 230.8, respectively). 
      Patients with Class III and IV LN had increased glomerular expression of both 
      MCP-1 and PGM1 compared to the other classes (P = 0.01) with Class IV-G LN 
      patients having the most glomerular expression of MCP-1 (median of 227.3) and 
      PGM1 (median of 237.5) and the worst renal prognosis (with proteinuria and 
      reduced eGFR). CONCLUSIONS: There is a correlation between glomerular expression 
      of MCP-1 and PGM1 and worsening renal prognosis in paediatric LN. Larger 
      prospective studies of paediatric LN are required to further evaluate MCP-1 and 
      other markers of disease progression.
FAU - Marks, Stephen D
AU  - Marks SD
AD  - Institute of Child Health, 30 Guilford Street, London, UK. s.marks@ich.ucl.ac.uk
FAU - Williams, Sue J
AU  - Williams SJ
FAU - Tullus, Kjell
AU  - Tullus K
FAU - Sebire, Neil J
AU  - Sebire NJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080521
PL  - England
TA  - Nephrol Dial Transplant
JT  - Nephrology, dialysis, transplantation : official publication of the European 
      Dialysis and Transplant Association - European Renal Association
JID - 8706402
RN  - 0 (Biomarkers)
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - EC 5.4.2.2 (PGM1 protein, human)
RN  - EC 5.4.2.2 (Phosphoglucomutase)
SB  - IM
MH  - Adolescent
MH  - Biomarkers/metabolism
MH  - Biopsy
MH  - Chemokine CCL2/*metabolism
MH  - Child
MH  - Disease Progression
MH  - Female
MH  - Humans
MH  - Kidney Glomerulus/*metabolism/pathology
MH  - Lupus Nephritis/*diagnosis/*metabolism/pathology
MH  - Macrophages/pathology
MH  - Male
MH  - Phosphoglucomutase/metabolism
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - Retrospective Studies
EDAT- 2008/05/23 09:00
MHDA- 2009/03/03 09:00
CRDT- 2008/05/23 09:00
PHST- 2008/05/23 09:00 [pubmed]
PHST- 2009/03/03 09:00 [medline]
PHST- 2008/05/23 09:00 [entrez]
AID - gfn270 [pii]
AID - 10.1093/ndt/gfn270 [doi]
PST - ppublish
SO  - Nephrol Dial Transplant. 2008 Nov;23(11):3521-6. doi: 10.1093/ndt/gfn270. Epub 
      2008 May 21.