PMID- 18497094
OWN - NLM
STAT- MEDLINE
DCOM- 20080807
LR  - 20191110
IS  - 1528-2511 (Print)
IS  - 1528-2511 (Linking)
VI  - 289
DP  - 2008
TI  - Neurotrophins in depression and antidepressant effects.
PG  - 43-52; discussion 53-9, 87-93
AB  - Neurotrophins are important regulators of neuronal plasticity in the developing 
      and adult brain. In particular, brain-derived neurotrophic factor (BDNF) and its 
      receptor TrkB are implicated in these functions. The synthesis and release of 
      BDNF is regulated by neuronal activity, and synaptic reorganization mediated by 
      BDNF is thought to be a critical process which shapes neuronal networks to code 
      optimally for environmentally relevant information. Recent evidence links 
      neuronal plasticity and neurotrophin signalling in mood disorders. A polymorphism 
      in the BDNF gene has been associated with depression and bipolar disorder. BDNF 
      levels are reduced in postmortem brain samples and in the blood of depressed 
      patients, and these reductions are reversible by successful antidepressant 
      treatment. Furthermore, BDNF signalling plays a critical role in the mechanism of 
      antidepressant drug action; at least in rodents, BDNF signalling appears to be 
      both necessary and sufficient for the behavioural effects produced by 
      antidepressant drugs. These data suggest that neurotrophin-mediated neuronal 
      plasticity is a critical factor in mood disorders and in their therapy. 
      Antidepressant treatments may, through enhanced BDNF signalling, improve the 
      ability of critical brain circuits to respond optimally to environmental demands, 
      a process that may be critical in the recovery from depression.
FAU - Castren, Eero
AU  - Castren E
AD  - Neuroscience Center, University of Helsinki, PO Box 56, 00014 Helsinki, Finland.
FAU - Rantamaki, Tomi
AU  - Rantamaki T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Novartis Found Symp
JT  - Novartis Foundation symposium
JID - 9807767
RN  - 0 (Antidepressive Agents)
RN  - 0 (Nerve Growth Factors)
SB  - IM
MH  - Antidepressive Agents/*therapeutic use
MH  - Depression/*drug therapy/*physiopathology
MH  - Humans
MH  - Mood Disorders/physiopathology
MH  - Nerve Growth Factors/*physiology
MH  - Nerve Net/drug effects/physiology/physiopathology
RF  - 36
EDAT- 2008/05/24 09:00
MHDA- 2008/08/08 09:00
CRDT- 2008/05/24 09:00
PHST- 2008/05/24 09:00 [pubmed]
PHST- 2008/08/08 09:00 [medline]
PHST- 2008/05/24 09:00 [entrez]
AID - 10.1002/9780470751251.ch4 [doi]
PST - ppublish
SO  - Novartis Found Symp. 2008;289:43-52; discussion 53-9, 87-93. doi: 
      10.1002/9780470751251.ch4.