PMID- 18497095
OWN - NLM
STAT- MEDLINE
DCOM- 20080807
LR  - 20191110
IS  - 1528-2511 (Print)
IS  - 1528-2511 (Linking)
VI  - 289
DP  - 2008
TI  - Genetics of bipolar disorder: focus on BDNF Val66Met polymorphism.
PG  - 60-72; discussion 72-3, 87-93
AB  - Bipolar disorder is a chronic severe mood disorder that has been consistently 
      demonstrated to have a strong inherited component. Traditional approaches to gene 
      discovery have produced conflicting results regarding the association between 
      genes and bipolar disorder. Numerous genes have been proposed as associated with 
      bipolar disorder. This paper will focus on one of these, brain-derived 
      neurotrophic factor (BDNF). BDNF is an interesting candidate gene for bipolar 
      disorder because of its important role in the neurodevelopment of the CNS. 
      Previous genetic work has identified a potential association between a Val66Met 
      polymorphism in the BDNF gene and bipolar disorder. Meta-analysis based on all 
      original published association studies between the Val66Met polymorphism and 
      bipolar disorder up to May 2007 shows modest but statistically significant 
      evidence for the association between the Val66Met polymorphism and bipolar 
      disorder (random-effects pooled odds ratio [OR] = 1.13, 95% Confidence Interval 
      [CI] = 1.04-1.23, Z = 2.85, P = 0.004) from 14 studies consisting of 4248 cases, 
      7080 control subjects and 858 nuclear families. Further large-scale studies are 
      warranted to elucidate the relevant BDNF gene variation(s) that act as risk 
      factors for bipolar disorder susceptibility.
FAU - Fan, Jinbo
AU  - Fan J
AD  - Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetics 
      Research, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, 
      USA.
FAU - Sklar, Pamela
AU  - Sklar P
LA  - eng
GR  - MH062137/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Novartis Found Symp
JT  - Novartis Foundation symposium
JID - 9807767
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - AE28F7PNPL (Methionine)
RN  - HG18B9YRS7 (Valine)
SB  - IM
MH  - Amino Acid Substitution
MH  - Bipolar Disorder/*genetics
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Case-Control Studies
MH  - Confidence Intervals
MH  - Genetic Predisposition to Disease
MH  - *Genetic Variation
MH  - Humans
MH  - Meta-Analysis as Topic
MH  - Methionine
MH  - Odds Ratio
MH  - *Polymorphism, Single Nucleotide
MH  - Risk Factors
MH  - Valine
RF  - 52
EDAT- 2008/05/24 09:00
MHDA- 2008/08/08 09:00
CRDT- 2008/05/24 09:00
PHST- 2008/05/24 09:00 [pubmed]
PHST- 2008/08/08 09:00 [medline]
PHST- 2008/05/24 09:00 [entrez]
AID - 10.1002/9780470751251.ch5 [doi]
PST - ppublish
SO  - Novartis Found Symp. 2008;289:60-72; discussion 72-3, 87-93. doi: 
      10.1002/9780470751251.ch5.