PMID- 18498296
OWN - NLM
STAT- MEDLINE
DCOM- 20080905
LR  - 20081121
IS  - 0001-2815 (Print)
IS  - 0001-2815 (Linking)
VI  - 72
IP  - 1
DP  - 2008 Jul
TI  - Investigation of killer cell immunoglobulin-like receptor (KIR) gene diversity: 
      KIR2DL2, KIR2DL5 and KIR2DS5.
PG  - 11-20
LID - 10.1111/j.1399-0039.2008.01050.x [doi]
AB  - Human killer cell immunoglobulin-like receptor (KIR) genes are important for 
      restraining natural killer cytotoxicity toward cells with autologous human 
      leukocyte antigen (HLA) while targeting cells lacking or expressing low levels of 
      self-HLA molecules. KIR gene content and alleles vary across individual genomes 
      and populations, requiring specialized laboratory tools for their 
      characterization. Here, we detail methods based on sequence-specific polymerase 
      chain reaction amplification and oligonucleotide probe hybridization to identify 
      alleles of KIR2DL2, KIR2DL5A, KIR2DL5B and KIR2DS5. Allele frequencies for a 
      Northern Irish population of 354 individuals typed with this system are given, 
      along with results from 132 cell lines from the International Histocompatibility 
      Workshop that cover many world populations. This information complements 
      published reports by our laboratory for allele-level typing of other KIR members, 
      totaling 12 of the 17 known genes. These methods are allowing us to characterize 
      KIR haplotypes in our population.
FAU - Gonzalez, A
AU  - Gonzalez A
AD  - Northern Ireland Regional Histocompatibility and Immunogenetics Laboratory, City 
      Hospital, Belfast, UK. asensio.gonzalez@belfasttrust.hscni.net
FAU - Meenagh, A
AU  - Meenagh A
FAU - Sleator, C
AU  - Sleator C
FAU - Middleton, D
AU  - Middleton D
LA  - eng
PT  - Journal Article
DEP - 20080520
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (KIR2DL2 protein, human)
RN  - 0 (KIR2DL3 protein, human)
RN  - 0 (KIR2DL5A protein, human)
RN  - 0 (KIR2DL5B protein, human)
RN  - 0 (Receptors, KIR)
RN  - 0 (Receptors, KIR2DL2)
RN  - 0 (Receptors, KIR2DL3)
RN  - 0 (Receptors, KIR2DL5)
SB  - IM
MH  - Cell Line
MH  - *Gene Frequency
MH  - *Genetic Variation
MH  - Haplotypes
MH  - Humans
MH  - Nucleic Acid Hybridization
MH  - Polymerase Chain Reaction
MH  - Receptors, KIR/*genetics
MH  - Receptors, KIR2DL2/genetics
MH  - Receptors, KIR2DL3/genetics
MH  - Receptors, KIR2DL5/genetics
EDAT- 2008/05/24 09:00
MHDA- 2008/09/06 09:00
CRDT- 2008/05/24 09:00
PHST- 2008/05/24 09:00 [pubmed]
PHST- 2008/09/06 09:00 [medline]
PHST- 2008/05/24 09:00 [entrez]
AID - TAN1050 [pii]
AID - 10.1111/j.1399-0039.2008.01050.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2008 Jul;72(1):11-20. doi: 10.1111/j.1399-0039.2008.01050.x. 
      Epub 2008 May 20.