PMID- 18500990
OWN - NLM
STAT- MEDLINE
DCOM- 20080721
LR  - 20211020
IS  - 1474-760X (Electronic)
IS  - 1465-6906 (Print)
IS  - 1474-7596 (Linking)
VI  - 9
IP  - 5
DP  - 2008
TI  - GeneCount: genome-wide calculation of absolute tumor DNA copy numbers from array 
      comparative genomic hybridization data.
PG  - R86
LID - 10.1186/gb-2008-9-5-r86 [doi]
AB  - Absolute tumor DNA copy numbers can currently be achieved only on a single gene 
      basis by using fluorescence in situ hybridization (FISH). We present GeneCount, a 
      method for genome-wide calculation of absolute copy numbers from clinical array 
      comparative genomic hybridization data. The tumor cell fraction is reliably 
      estimated in the model. Data consistent with FISH results are achieved. We 
      demonstrate significant improvements over existing methods for exploring gene 
      dosages and intratumor copy number heterogeneity in cancers.
FAU - Lyng, Heidi
AU  - Lyng H
AD  - Department of Radiation Biology, Institute for Cancer Research, Norwegian Radium 
      Hospital, Montebello, NO-0310 Oslo, Norway. heidi.lyng@rr-research.no
FAU - Lando, Malin
AU  - Lando M
FAU - Brovig, Runar S
AU  - Brovig RS
FAU - Svendsrud, Debbie H
AU  - Svendsrud DH
FAU - Johansen, Morten
AU  - Johansen M
FAU - Galteland, Eivind
AU  - Galteland E
FAU - Brustugun, Odd T
AU  - Brustugun OT
FAU - Meza-Zepeda, Leonardo A
AU  - Meza-Zepeda LA
FAU - Myklebost, Ola
AU  - Myklebost O
FAU - Kristensen, Gunnar B
AU  - Kristensen GB
FAU - Hovig, Eivind
AU  - Hovig E
FAU - Stokke, Trond
AU  - Stokke T
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080523
PL  - England
TA  - Genome Biol
JT  - Genome biology
JID - 100960660
RN  - 0 (DNA, Neoplasm)
SB  - IM
MH  - Carcinoma, Squamous Cell/genetics
MH  - DNA, Neoplasm/*genetics
MH  - Female
MH  - *Gene Dosage
MH  - Humans
MH  - Lymphoma, Non-Hodgkin/genetics
MH  - Nucleic Acid Hybridization/*methods
MH  - Translocation, Genetic
MH  - Uterine Cervical Neoplasms/genetics
PMC - PMC2441472
EDAT- 2008/05/27 09:00
MHDA- 2008/07/22 09:00
PMCR- 2008/05/23
CRDT- 2008/05/27 09:00
PHST- 2008/01/18 00:00 [received]
PHST- 2008/04/23 00:00 [revised]
PHST- 2008/05/23 00:00 [accepted]
PHST- 2008/05/27 09:00 [pubmed]
PHST- 2008/07/22 09:00 [medline]
PHST- 2008/05/27 09:00 [entrez]
PHST- 2008/05/23 00:00 [pmc-release]
AID - gb-2008-9-5-r86 [pii]
AID - 10.1186/gb-2008-9-5-r86 [doi]
PST - ppublish
SO  - Genome Biol. 2008;9(5):R86. doi: 10.1186/gb-2008-9-5-r86. Epub 2008 May 23.