PMID- 18501457
OWN - NLM
STAT- MEDLINE
DCOM- 20081126
LR  - 20221207
IS  - 0168-0102 (Print)
IS  - 0168-0102 (Linking)
VI  - 61
IP  - 4
DP  - 2008 Aug
TI  - Dose-dependent effect of the Val66Met polymorphism of the brain-derived 
      neurotrophic factor gene on memory-related hippocampal activity.
PG  - 360-7
LID - 10.1016/j.neures.2008.04.003 [doi]
AB  - Brain-derived neurotrophic factor (BDNF) plays a critical role in 
      activity-dependent neuroplasticity underlying learning and memory in the 
      hippocampus. Recent human studies have indicated that a common single nucleotide 
      polymorphism of the BDNF gene, the Val66Met polymorphism, has impact on episodic 
      memory, hippocampal morphology and memory-related hippocampal activity measured 
      by functional magnetic resonance imaging (fMRI). However, two issues remain to be 
      clarified: (1) whether the genotype effect of this polymorphism on memory-related 
      brain activity is allele dose dependent and (2) whether the effect of this 
      polymorphism in Asian population is the same as effects observed in Caucasian 
      sample. To clarify these issues, we studied the relationship of the Val66Met 
      polymorphism genotype and hippocampal activity during episodic memory task using 
      fMRI in healthy 58 biologically unrelated Japanese. Although there was no 
      genotype effect on episodic memory function obtained by behavioral assessments, 
      fMRI measurements revealed a significantly negative correlation between the dose 
      of Met-BDNF allele and encoding related brain activity in the bilateral 
      hippocampi and right parahippocampal gyrus. There was no genotype effect on 
      retrieval related brain activity. These data indicated a genetic mechanism for 
      normal variation in human memory and suggest effects of BDNF signaling on 
      hippocampal function in humans.
FAU - Hashimoto, Ryota
AU  - Hashimoto R
AD  - The Osaka-Hamamatsu Joint Research Center For Child Mental Development, Osaka 
      University Graduate School of Medicine, Suita, Osaka, Japan. 
      hashimor@psy.med.osaka-u.ac.jp
FAU - Moriguchi, Yoshiya
AU  - Moriguchi Y
FAU - Yamashita, Fumio
AU  - Yamashita F
FAU - Mori, Takeyuki
AU  - Mori T
FAU - Nemoto, Kiyotaka
AU  - Nemoto K
FAU - Okada, Takeya
AU  - Okada T
FAU - Hori, Hiroaki
AU  - Hori H
FAU - Noguchi, Hiroko
AU  - Noguchi H
FAU - Kunugi, Hiroshi
AU  - Kunugi H
FAU - Ohnishi, Takashi
AU  - Ohnishi T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080420
PL  - Ireland
TA  - Neurosci Res
JT  - Neuroscience research
JID - 8500749
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - AE28F7PNPL (Methionine)
RN  - HG18B9YRS7 (Valine)
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Adult
MH  - Asian People
MH  - Brain Mapping
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Female
MH  - Gene Frequency
MH  - Genotype
MH  - Hippocampus/blood supply/*physiology
MH  - Humans
MH  - Image Processing, Computer-Assisted
MH  - Magnetic Resonance Imaging/methods
MH  - Male
MH  - Memory/*physiology
MH  - Methionine/*genetics
MH  - Middle Aged
MH  - Neuropsychological Tests
MH  - Oxygen/blood
MH  - *Polymorphism, Single Nucleotide
MH  - Valine/*genetics
EDAT- 2008/05/27 09:00
MHDA- 2008/12/17 09:00
CRDT- 2008/05/27 09:00
PHST- 2007/07/03 00:00 [received]
PHST- 2008/04/08 00:00 [revised]
PHST- 2008/04/11 00:00 [accepted]
PHST- 2008/05/27 09:00 [pubmed]
PHST- 2008/12/17 09:00 [medline]
PHST- 2008/05/27 09:00 [entrez]
AID - S0168-0102(08)00116-8 [pii]
AID - 10.1016/j.neures.2008.04.003 [doi]
PST - ppublish
SO  - Neurosci Res. 2008 Aug;61(4):360-7. doi: 10.1016/j.neures.2008.04.003. Epub 2008 
      Apr 20.