PMID- 18501627
OWN - NLM
STAT- MEDLINE
DCOM- 20081209
LR  - 20211020
IS  - 1095-9327 (Electronic)
IS  - 1044-7431 (Print)
IS  - 1044-7431 (Linking)
VI  - 38
IP  - 3
DP  - 2008 Jul
TI  - Ankyrin-rich membrane spanning protein plays a critical role in nuclear 
      factor-kappa B signaling.
PG  - 404-16
LID - 10.1016/j.mcn.2008.04.001 [doi]
AB  - Activation of nuclear factor-kappaB (NF-kappaB), a key feature of the 
      neurotrophin signaling, has been shown to be critical for neuronal survival under 
      pathologic settings. However, the precise mechanism by which neurotrophins 
      activate NF-kappaB is not well understood. Here we report that the Ankyrin-rich 
      Membrane Spanning (ARMS/Kidins220) protein, a novel transmembrane substrate of 
      tropomyosin receptor kinase B (TrkB), plays an important role in NF-kappaB 
      signaling elicited by brain-derived neurotrophic factor (BDNF). Accordingly, 
      depletion of ARMS by specific RNA interference, or disruption of ARMS-TrkB 
      interaction with expression of dominant-negative ARMS mutant, abolished 
      BDNF-induced signaling to NF-kappaB. Our data further suggests that ARMS may 
      promote NF-kappaB signaling via activation of mitogen-activated kinase (MAPK) and 
      IkappaB kinase (IKK), thereby facilitating phosphorylation of RelA (major 
      NF-kappaB subunit) at an IKK-sensitive site. The results shown here identify ARMS 
      as a major factor that links neurotrophin signaling to NF-kappaB.
FAU - Sniderhan, Lynn F
AU  - Sniderhan LF
AD  - Department of Microbiology and Immunology,University of Rochester Medical Center, 
      Rochester, NY 14642, USA.
FAU - Stout, Angela
AU  - Stout A
FAU - Lu, Yuanan
AU  - Lu Y
FAU - Chao, Moses V
AU  - Chao MV
FAU - Maggirwar, Sanjay B
AU  - Maggirwar SB
LA  - eng
GR  - R01 NS054578/NS/NINDS NIH HHS/United States
GR  - P01 HD023315/HD/NICHD NIH HHS/United States
GR  - NS21072/NS/NINDS NIH HHS/United States
GR  - S11 NS043499-05/NS/NINDS NIH HHS/United States
GR  - R01 NS021072/NS/NINDS NIH HHS/United States
GR  - R01 NS066801/NS/NINDS NIH HHS/United States
GR  - P01 MH064570-040003/MH/NIMH NIH HHS/United States
GR  - HD23315/HD/NICHD NIH HHS/United States
GR  - P01 MH064570/MH/NIMH NIH HHS/United States
GR  - T32 AI49105/AI/NIAID NIH HHS/United States
GR  - R56 NS021072/NS/NINDS NIH HHS/United States
GR  - S11 NS043499-04/NS/NINDS NIH HHS/United States
GR  - T32 AI049815/AI/NIAID NIH HHS/United States
GR  - S11 NS043499-03/NS/NINDS NIH HHS/United States
GR  - S11NS043499/NS/NINDS NIH HHS/United States
GR  - P01 MH64570/MH/NIMH NIH HHS/United States
GR  - S11 NS043499/NS/NINDS NIH HHS/United States
GR  - R01 NS054578-03/NS/NINDS NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20080416
PL  - United States
TA  - Mol Cell Neurosci
JT  - Molecular and cellular neurosciences
JID - 9100095
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (KIDINS220 protein, human)
RN  - 0 (Membrane Proteins)
RN  - 0 (NF-kappa B)
RN  - 0 (Nerve Tissue Proteins)
SB  - IM
MH  - Animals
MH  - Ankyrin Repeat/*physiology
MH  - Brain-Derived Neurotrophic Factor/metabolism/physiology
MH  - Cell Communication/physiology
MH  - Cell Line
MH  - Cell Survival/physiology
MH  - Cells, Cultured
MH  - Humans
MH  - Membrane Proteins/metabolism/*physiology
MH  - NF-kappa B/metabolism/*physiology
MH  - Nerve Tissue Proteins/metabolism/*physiology
MH  - Rats
MH  - Signal Transduction/*physiology
PMC - PMC2577916
MID - NIHMS59024
EDAT- 2008/05/27 09:00
MHDA- 2008/12/17 09:00
PMCR- 2009/07/01
CRDT- 2008/05/27 09:00
PHST- 2008/02/20 00:00 [received]
PHST- 2008/03/24 00:00 [revised]
PHST- 2008/04/02 00:00 [accepted]
PHST- 2008/05/27 09:00 [pubmed]
PHST- 2008/12/17 09:00 [medline]
PHST- 2008/05/27 09:00 [entrez]
PHST- 2009/07/01 00:00 [pmc-release]
AID - S1044-7431(08)00093-6 [pii]
AID - 10.1016/j.mcn.2008.04.001 [doi]
PST - ppublish
SO  - Mol Cell Neurosci. 2008 Jul;38(3):404-16. doi: 10.1016/j.mcn.2008.04.001. Epub 
      2008 Apr 16.