PMID- 18501671
OWN - NLM
STAT- MEDLINE
DCOM- 20081118
LR  - 20110608
IS  - 1388-9842 (Print)
IS  - 1388-9842 (Linking)
VI  - 10
IP  - 6
DP  - 2008 Jun
TI  - Serum carbohydrate antigen 125 levels in advanced heart failure: relation to 
      B-type natriuretic peptide and left atrial volume.
PG  - 556-9
LID - 10.1016/j.ejheart.2008.04.012 [doi]
AB  - AIMS: To assess the relation between serum levels of carbohydrate antigen 125 (CA 
      125) and parameters of left ventricular (LV) filling pressure in patients with 
      advanced heart failure (AHF). METHODS: Forty-nine patients (mean age 67+/-10 
      years) with LV ejection fraction (EF) < or =0.35 and New York Heart Association 
      (NYHA) class III or IV symptoms of heart failure were enrolled. Left atrial 
      volume indexed to body surface area (LAVI) and the ratio of mitral inflow early 
      diastolic velocity to annulus velocity (E/e) were evaluated with pulsed wave and 
      tissue Doppler. Plasma B-type natriuretic peptide (BNP) was also measured. 
      RESULTS: The median overall CA 125 value was 44.0 (17.7-140) U/ml. CA 125 above 
      the normal value (<35 U/ml) was found in 28 of the 49 patients (57%). Compared to 
      patients with normal CA 125 levels, those with elevated CA 125 had a higher NYHA 
      class and increased serum BNP levels, LAVI and E/e. In multivariate analysis, 
      serum CA 125 levels were significantly associated with BNP (standardized beta 
      coefficient=0.58, p<0.001) and LAVI (standardized beta coefficient 0.34, 
      p<0.005). CONCLUSION: Our study demonstrates that elevated serum CA 125 levels 
      are associated with increased LAVI in parallel to increased neurohormonal 
      activation in patients with AHF.
FAU - Duman, Dursun
AU  - Duman D
AD  - Haydarpasa Numune Training and Research Hospital, Department of Cardiology, 
      Tibbiye Caddesi, Kadikoy/Istanbul, Turkey. drduman@excite.com
FAU - Palit, Fatih
AU  - Palit F
FAU - Simsek, Ergun
AU  - Simsek E
FAU - Bilgehan, Karadag
AU  - Bilgehan K
LA  - eng
PT  - Journal Article
DEP - 20080523
PL  - England
TA  - Eur J Heart Fail
JT  - European journal of heart failure
JID - 100887595
RN  - 0 (CA-125 Antigen)
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
SB  - IM
MH  - Aged
MH  - CA-125 Antigen/*blood
MH  - Cardiac Volume/*physiology
MH  - Cohort Studies
MH  - Female
MH  - Heart Atria
MH  - Heart Failure/*blood/complications/*physiopathology
MH  - Humans
MH  - Linear Models
MH  - Male
MH  - Middle Aged
MH  - Natriuretic Peptide, Brain/*blood
MH  - Predictive Value of Tests
MH  - Severity of Illness Index
MH  - Stroke Volume/*physiology
EDAT- 2008/05/27 09:00
MHDA- 2008/11/19 09:00
CRDT- 2008/05/27 09:00
PHST- 2008/02/16 00:00 [received]
PHST- 2008/04/08 00:00 [revised]
PHST- 2008/04/28 00:00 [accepted]
PHST- 2008/05/27 09:00 [pubmed]
PHST- 2008/11/19 09:00 [medline]
PHST- 2008/05/27 09:00 [entrez]
AID - S1388-9842(08)00193-1 [pii]
AID - 10.1016/j.ejheart.2008.04.012 [doi]
PST - ppublish
SO  - Eur J Heart Fail. 2008 Jun;10(6):556-9. doi: 10.1016/j.ejheart.2008.04.012. Epub 
      2008 May 23.