PMID- 18501813
OWN - NLM
STAT- MEDLINE
DCOM- 20080609
LR  - 20161124
IS  - 1879-1190 (Electronic)
IS  - 1072-7515 (Linking)
VI  - 206
IP  - 6
DP  - 2008 Jun
TI  - Cystic pancreatic endocrine neoplasms: a distinct tumor type?
PG  - 1154-8
LID - 10.1016/j.jamcollsurg.2007.12.040 [doi]
AB  - BACKGROUND: Cystic pancreatic endocrine neoplasms (CPENs) are considered rare, 
      and their behavior is thought to be similar to that of solid pancreatic endocrine 
      neoplasms (PENs). This study aims to describe the characteristics of CPENs in a 
      large patient cohort. STUDY DESIGN: We performed a retrospective review of 170 
      patients who underwent resections for PENs at Massachusetts General Hospital from 
      1977 to 2006. Twenty-nine patients (51% men, mean age 53) with CPENs were 
      compared with 141 patients with solid PENs. Differences in clinical presentation, 
      pathologic and radiographic features, and survival were described. RESULTS: CPENs 
      comprised 17% of all PENs (29 of 170) and 5.4% of all resected cystic pancreatic 
      neoplasms(29 of 535). Ten (34%) were purely cystic and 19 (66%) were partially 
      cystic. Compared with solid PENs, CPENs were larger (49 mm versus 23.5 mm, p < 
      0.05), more likely symptomatic (73% versus 45%, p < 0.05), and more likely 
      nonfunctional (80% versus 50%, p < 0.05). They expressed synaptophysin (100%), 
      chromogranin (82%), and cytokeratin (CK)-19 (24%). Multiple endocrine neoplasia 
      type 1 (MEN-1) was 3.5 times more common in CPENs than in solid tumors (21% 
      versus 6%, p < 0.05). No significant difference was found in location, propensity 
      for metastasis, invasion, or 5-year survival (87% versus 77%, p=0.38). 
      CONCLUSIONS: This series, the largest report of CPENs in the literature, shows 
      that CPENs are more common than previously thought, so they should be included in 
      the differential of the cystic lesions of the pancreas. CPENs are larger and more 
      likely to be symptomatic then solid PENs. They are also more likely to be 
      associated with MEN-1 and to be nonfunctional, suggesting they may be a distinct 
      tumor type.
FAU - Bordeianou, Liliana
AU  - Bordeianou L
AD  - Department of Surgery, Massachusetts General Hospital and Harvard Medical School, 
      Boston, MA 02114, USA.
FAU - Vagefi, Parsia A
AU  - Vagefi PA
FAU - Sahani, Dushyant
AU  - Sahani D
FAU - Deshpande, Vikram
AU  - Deshpande V
FAU - Rakhlin, Elena
AU  - Rakhlin E
FAU - Warshaw, Andrew L
AU  - Warshaw AL
FAU - Fernandez-del Castillo, Carlos
AU  - Fernandez-del Castillo C
LA  - eng
PT  - Journal Article
DEP - 20080414
PL  - United States
TA  - J Am Coll Surg
JT  - Journal of the American College of Surgeons
JID - 9431305
SB  - IM
MH  - Age Distribution
MH  - Diagnosis, Differential
MH  - Female
MH  - Glucagonoma/diagnosis/pathology/surgery
MH  - Humans
MH  - Insulinoma/diagnosis/pathology/surgery
MH  - Male
MH  - Middle Aged
MH  - Pancreatic Cyst/*diagnostic imaging/*pathology/surgery
MH  - Pancreatic Neoplasms/*diagnostic imaging/*pathology/surgery
MH  - Retrospective Studies
MH  - Sex Distribution
MH  - Tomography, X-Ray Computed
EDAT- 2008/05/27 09:00
MHDA- 2008/06/10 09:00
CRDT- 2008/05/27 09:00
PHST- 2007/08/24 00:00 [received]
PHST- 2007/10/31 00:00 [revised]
PHST- 2007/12/03 00:00 [accepted]
PHST- 2008/05/27 09:00 [pubmed]
PHST- 2008/06/10 09:00 [medline]
PHST- 2008/05/27 09:00 [entrez]
AID - S1072-7515(08)00024-0 [pii]
AID - 10.1016/j.jamcollsurg.2007.12.040 [doi]
PST - ppublish
SO  - J Am Coll Surg. 2008 Jun;206(6):1154-8. doi: 10.1016/j.jamcollsurg.2007.12.040. 
      Epub 2008 Apr 14.