PMID- 18501999
OWN - NLM
STAT- MEDLINE
DCOM- 20080909
LR  - 20080613
IS  - 0264-410X (Print)
IS  - 0264-410X (Linking)
VI  - 26
IP  - 27-28
DP  - 2008 Jun 25
TI  - HLA and response to booster hepatitis B vaccination in anti-HBs-seronegative 
      adolescents who had received primary infantile vaccination.
PG  - 3414-20
LID - 10.1016/j.vaccine.2008.04.038 [doi]
AB  - To explore contemporarily genetic and non-genetic determinants of long-term 
      immunological memory to hepatitis B (HB) vaccination, we conducted a case-control 
      study nested in an adolescent cohort of booster recipients who had received 
      primary infantile HB vaccination but with residual anti-HBs titers <10 mIU/mL at 
      15-18 years of age. High-resolution phenotypes of human leukocyte antigen 
      (HLA)-A, -B, and -DRB1 loci were determined by sequence-specific oligonucleotide 
      probe hybridization. After controlling for pre-booster anti-HBs levels, the 
      absences of HLA-A*02 and -DRB1*08, simply expressed as A*02(-) and -DRB1*08(-), 
      and the presence of B*15 were significantly associated with elevated risks of 
      non-response (post-booster anti-HBs titers<10 mIU/mL) to booster vaccination. The 
      adjusted odds ratios (ORs) were 3.85 (CI, 1.82-8.33), 4.55 (CI, 1.23-16.67), 3.59 
      (CI, 1.40-9.17), respectively. There was multiplicative synergism between A*02 
      and B*15 on the risk of non-response to booster vaccination. The 
      multivariate-adjusted ORs for A*02(-)/B*15, A*02(-)/B*15(-), A*02/B*15, and 
      A*02/B*15(-) haplotypes were 20.39 (p=0.0003), 3.29 (p=0.007), 1.32 (p>0.05), and 
      1.0, respectively. Recent cigarette smoking and/or betel-quid chewing was 
      associated with a 12-fold risk of non-response to booster vaccination. Further 
      comparisons between responders and adolescents who had undetectable post-booster 
      anti-HBs titers (<0.1 mIU/mL) demonstrated similar results. Our results indicated 
      that response to booster HB vaccination as well as long-term immunological 
      responses to HB vaccination are closely related with host genetic factors, and 
      probably modified by recent substance use.
FAU - Lin, Hans Hsienhong
AU  - Lin HH
AD  - Department of Internal Medicine, Tzu Chi University, Hualien, Taiwan.
FAU - Liao, Huei-Wen Chang
AU  - Liao HW
FAU - Lin, Sheng-Kai
AU  - Lin SK
FAU - Wang, Li-Yu
AU  - Wang LY
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080505
PL  - Netherlands
TA  - Vaccine
JT  - Vaccine
JID - 8406899
RN  - 0 (DNA Primers)
RN  - 0 (HLA Antigens)
RN  - 0 (Hepatitis B Antibodies)
RN  - 0 (Hepatitis B Vaccines)
SB  - IM
MH  - Adolescent
MH  - Case-Control Studies
MH  - DNA Primers
MH  - Female
MH  - HLA Antigens/*genetics
MH  - Hepatitis B/prevention & control
MH  - Hepatitis B Antibodies/*blood
MH  - Hepatitis B Vaccines/*immunology
MH  - Humans
MH  - Immunization, Secondary
MH  - Male
MH  - Nucleic Acid Hybridization
EDAT- 2008/05/27 09:00
MHDA- 2008/09/10 09:00
CRDT- 2008/05/27 09:00
PHST- 2008/01/22 00:00 [received]
PHST- 2008/03/11 00:00 [revised]
PHST- 2008/04/15 00:00 [accepted]
PHST- 2008/05/27 09:00 [pubmed]
PHST- 2008/09/10 09:00 [medline]
PHST- 2008/05/27 09:00 [entrez]
AID - S0264-410X(08)00492-1 [pii]
AID - 10.1016/j.vaccine.2008.04.038 [doi]
PST - ppublish
SO  - Vaccine. 2008 Jun 25;26(27-28):3414-20. doi: 10.1016/j.vaccine.2008.04.038. Epub 
      2008 May 5.