PMID- 18503170
OWN - NLM
STAT- MEDLINE
DCOM- 20081007
LR  - 20080526
IS  - 1344-6304 (Print)
IS  - 1344-6304 (Linking)
VI  - 61
IP  - 3
DP  - 2008 May
TI  - Immune reconstitution inflammatory syndrome among HIV/AIDS patients during highly 
      active antiretroviral therapy in Addis Ababa, Ethiopia.
PG  - 205-9
AB  - Suppression of viral replication is followed by increases in CD4+ lymphocytes, 
      and this has been shown to result in decreased susceptibility to opportunists 
      after initiation of highly active antiretroviral therapy (HAART). However, 
      clinical aggravations after the initiation of HAART have been thought to be due 
      to the restored ability to mount an inflammatory response, or the immune 
      reconstitution inflammatory syndrome (IRIS). The degree of IRIS observed in human 
      immunodeficiency virus (HIV)-infected patients following initiation of HAART is 
      variable. This prospective study was aimed at determining the proportion of IRIS 
      and the pattern of opportunistic infections among 186 HIV/AIDS patients receiving 
      HAART between December 2006 and July 2007 at Zewditu Memorial Hospital, Addis 
      Ababa, Ethiopia. The proportion of IRIS was 17.2% (32/186). The mean number of 
      days of IRIS occurrence for each disease ranged from 26 to 122 days with a mean 
      of 80. Opportunistic diseases associated with IRIS were tuberculosis (68.8%, 
      22/32), herpes zoster rash (12.5%, 4/32), cryptococcosis (9.4%, 3/32), 
      toxoplasmosis (6.3%, 2/32) and bacterial pneumonia (3.1%, 1/32). Compared to 
      baseline readings there were significant increases in CD4 count, aspartate 
      aminotransferase and alanine aminotransferase levels while hemoglobin values 
      decreased during the development of IRIS. In summary, the proportion of IRIS and 
      the pattern of opportunistic infections in HAART-treated patients in Ethiopia 
      mirrored those reported in other countries. Further prospective surveys on 
      epidemiological, immunological, microbial and clinical studies are imperative to 
      assess the proportion and pattern of IRIS and effect of HAART in Ethiopia.
FAU - Huruy, Kahsay
AU  - Huruy K
AD  - Department of Medical Laboratory Technology, College of Medicine and Health 
      Sciences, University of Gondar, Gondar, Ethiopia. kasaye88@yahoo.com
FAU - Mulu, Andargachew
AU  - Mulu A
FAU - Mengistu, Getahun
AU  - Mengistu G
FAU - Shewa-Amare, Aster
AU  - Shewa-Amare A
FAU - Akalu, Addis
AU  - Akalu A
FAU - Kassu, Afework
AU  - Kassu A
FAU - Andargie, Gashaw
AU  - Andargie G
FAU - Elias, Daniel
AU  - Elias D
FAU - Torben, Workineh
AU  - Torben W
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Japan
TA  - Jpn J Infect Dis
JT  - Japanese journal of infectious diseases
JID - 100893704
SB  - IM
MH  - AIDS-Related Opportunistic Infections/epidemiology/etiology
MH  - Adult
MH  - *Antiretroviral Therapy, Highly Active
MH  - Ethiopia/epidemiology
MH  - Female
MH  - HIV Infections/complications/*drug therapy/*immunology
MH  - Humans
MH  - Immune Reconstitution Inflammatory Syndrome/*epidemiology/*etiology
MH  - Male
EDAT- 2008/05/27 09:00
MHDA- 2008/10/08 09:00
CRDT- 2008/05/27 09:00
PHST- 2008/05/27 09:00 [pubmed]
PHST- 2008/10/08 09:00 [medline]
PHST- 2008/05/27 09:00 [entrez]
PST - ppublish
SO  - Jpn J Infect Dis. 2008 May;61(3):205-9.