PMID- 18503219
OWN - NLM
STAT- MEDLINE
DCOM- 20080911
LR  - 20221207
IS  - 1346-9843 (Print)
IS  - 1346-9843 (Linking)
VI  - 72
IP  - 6
DP  - 2008 Jun
TI  - Small dense LDL-cholesterol relative to LDL-cholesterol is a strong independent 
      determinant of hypoadiponectinemia in metabolic syndrome.
PG  - 932-9
AB  - BACKGROUND: Small dense low-density lipoprotein (sd-LDL) is an atherogenic 
      lipoprotein closely associated with an increased risk of cardiovascular diseases. 
      However, a precise analysis of the actual amount of sd-LDL-cholesterol (sd-LDL-C) 
      in patients with metabolic syndrome (MS) has not been performed. METHODS AND 
      RESULTS: Among 214 patients enrolled in the present study, 101 patients (47%) met 
      the Japanese MS criteria. The serum levels of sd-LDL-C determined with a dual 
      detection HPLC system were higher in MS than non-MS patients, while total 
      cholesterol and low-density lipoprotein-cholesterol (LDL-C) were similar between 
      MS and non-MS patients. Compared with the sd-LDL-C and LDL-C level, the ratio 
      sd-LDL-C/LDL-C was more closely correlated with various parameters associated 
      with MS. A multivariate regression analysis revealed that the ratio 
      sd-LDL-C/LDL-C is the strongest independent determinant of hypoadiponectinemia. 
      Furthermore, weight reduction therapy through diet and exercise rapidly decreased 
      LDL-C but slowly decreased sd-LDL-C. At 12 months after the therapy, weight 
      reduction led to a significant decrease in the ratio sd-LDL-C/LDL-C in tandem 
      with increasing adiponectin levels. CONCLUSIONS: These findings demonstrate that 
      the ratio sd-LDL-C/LDL-C is tightly connected with hypoadiponectinemia and 
      provides a useful clinical indicator for MS. The results also suggest that the 
      elevation of this ratio can be modulated by long-term lifestyle changes.
FAU - Satoh, Noriko
AU  - Satoh N
AD  - Division of Metabolic Research, Clinical Research Institute for Endocrine and 
      Metabolic Diseases, National Hospital Organization, Kyoto Medical Center, 1-1 
      Fukakusa, Mukaihata-cho, Fushimi-ku, Kyoto 612-8555, Japan. 
      nsato@kyotolan.hosp.go.jp
FAU - Wada, Hiromichi
AU  - Wada H
FAU - Ono, Koh
AU  - Ono K
FAU - Yamakage, Hajime
AU  - Yamakage H
FAU - Yamada, Kazunori
AU  - Yamada K
FAU - Nakano, Tameo
AU  - Nakano T
FAU - Hattori, Masakazu
AU  - Hattori M
FAU - Shimatsu, Akira
AU  - Shimatsu A
FAU - Kuzuya, Hideshi
AU  - Kuzuya H
FAU - Hasegawa, Koji
AU  - Hasegawa K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Japan
TA  - Circ J
JT  - Circulation journal : official journal of the Japanese Circulation Society
JID - 101137683
RN  - 0 (ADIPOQ protein, human)
RN  - 0 (Adiponectin)
RN  - 0 (Cholesterol, LDL)
SB  - IM
MH  - Adiponectin/blood
MH  - Asian People/statistics & numerical data
MH  - Cholesterol, LDL/*blood/chemistry
MH  - Female
MH  - Humans
MH  - Japan/epidemiology
MH  - Life Style
MH  - Male
MH  - Metabolic Syndrome/*epidemiology/*metabolism
MH  - Middle Aged
MH  - Molecular Weight
MH  - Obesity/epidemiology/metabolism
MH  - Risk Factors
MH  - Weight Loss
EDAT- 2008/05/27 09:00
MHDA- 2008/09/13 09:00
CRDT- 2008/05/27 09:00
PHST- 2008/05/27 09:00 [pubmed]
PHST- 2008/09/13 09:00 [medline]
PHST- 2008/05/27 09:00 [entrez]
AID - JST.JSTAGE/circj/72.932 [pii]
AID - 10.1253/circj.72.932 [doi]
PST - ppublish
SO  - Circ J. 2008 Jun;72(6):932-9. doi: 10.1253/circj.72.932.