PMID- 18503831
OWN - NLM
STAT- MEDLINE
DCOM- 20080807
LR  - 20151119
IS  - 1873-4456 (Electronic)
IS  - 0165-4608 (Linking)
VI  - 183
IP  - 2
DP  - 2008 Jun
TI  - Double-minute MYC amplification and deletion of MTAP, CDKN2A, CDKN2B, and ELAVL2 
      in an acute myeloid leukemia characterized by oligonucleotide-array comparative 
      genomic hybridization.
PG  - 117-20
LID - 10.1016/j.cancergencyto.2008.02.011 [doi]
AB  - Chromosomal analysis and fluorescence in situ hybridization (FISH) have been 
      routinely used in detecting recurrent chromosomal abnormalities in patients with 
      various hematological malignancies. However, the genomic imbalances underlying 
      many recurrent abnormalities could not be delineated due to the low resolution of 
      chromosome analysis. We have performed oligonucleotide-array comparative genomic 
      hybridization (oaCGH) in an AML case with a 15p/17p translocation, a suspected 
      9p21 deletion, monosomies of chromosomes X and 9, and 2 to 60 double minutes. The 
      oaCGH findings confirmed the chromosomal observations and further characterized a 
      21.338-Mb 17p deletion, a 3.916-Mb deletion at 9p21.3 containing the MTAP, 
      CDKN2A, CDKN2B, and ELAVL2 genes, and a 3.981-Mb 8q24 double minute containing 
      the TRIB1, FAM84B, MYC, and PVT1 genes, with an average of 30 double minutes in 
      each cell. FISH using MYC probes and bacterial artificial chromosome clone probes 
      confirmed the genomic findings and revealed a progressional pattern for the 
      9p21.3 deletion. These results demonstrate the potential of oaCGH as a powerful 
      diagnostic tool for characterizing genomic imbalances for patients with 
      hematological malignancies.
CI  - (c) 2008 Elsevier Inc.
FAU - Kamath, Anitha
AU  - Kamath A
AD  - Molecular Cytogenetics Laboratory, Department of Genetics, Yale University School 
      of Medicine, 333 Cedar Street, New Haven, CT 06520, USA.
FAU - Tara, Harold
AU  - Tara H
FAU - Xiang, Bixia
AU  - Xiang B
FAU - Bajaj, Renu
AU  - Bajaj R
FAU - He, Wanping
AU  - He W
FAU - Li, Peining
AU  - Li P
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
RN  - 0 (Cyclin-Dependent Kinase Inhibitor p15)
RN  - 0 (Cyclin-Dependent Kinase Inhibitor p16)
RN  - 0 (ELAV Proteins)
RN  - 0 (ELAV-Like Protein 2)
RN  - 0 (ELAVL2 protein, human)
RN  - 0 (Microtubule-Associated Proteins)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Cyclin-Dependent Kinase Inhibitor p15/*genetics
MH  - Cyclin-Dependent Kinase Inhibitor p16/*genetics
MH  - ELAV Proteins/*genetics
MH  - ELAV-Like Protein 2
MH  - Female
MH  - *Genes, myc
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Leukemia, Myeloid, Acute/*genetics
MH  - Microtubule-Associated Proteins/*genetics
MH  - Oligonucleotide Array Sequence Analysis
EDAT- 2008/05/28 09:00
MHDA- 2008/08/08 09:00
CRDT- 2008/05/28 09:00
PHST- 2008/01/15 00:00 [received]
PHST- 2008/02/20 00:00 [accepted]
PHST- 2008/05/28 09:00 [pubmed]
PHST- 2008/08/08 09:00 [medline]
PHST- 2008/05/28 09:00 [entrez]
AID - S0165-4608(08)00147-7 [pii]
AID - 10.1016/j.cancergencyto.2008.02.011 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 2008 Jun;183(2):117-20. doi: 
      10.1016/j.cancergencyto.2008.02.011.