PMID- 18504634
OWN - NLM
STAT- MEDLINE
DCOM- 20081202
LR  - 20211020
IS  - 0940-1334 (Print)
IS  - 0940-1334 (Linking)
VI  - 258
IP  - 5
DP  - 2008 Aug
TI  - Visual sensory processing deficits in Schizophrenia and their relationship to 
      disease state.
PG  - 305-16
LID - 10.1007/s00406-008-0802-2 [doi]
AB  - CONTEXT: Visual Evoked Potential (VEP) abnormalities have been a fairly 
      consistent finding in patients with schizophrenia, and it has been suggested that 
      electrophysiological markers of early sensory processing may be useful as trait 
      markers for the illness, and for development as potential diagnostic measures. 
      OBJECTIVE: Clear amplitude reductions in the occipital P1 component of the VEP 
      (approximately 100 ms), have been repeatedly demonstrated in patients with 
      schizophrenia. Here, we investigated whether the extent of this deficit was 
      related to age, clinical symptoms, medication status and length of illness, in a 
      large cohort of ethnically homogenous patients. DESIGN, SETTING AND PARTICIPANTS: 
      VEP responses to simple isolated-check stimuli were examined in 52 DSM-IV 
      diagnosed patients with schizophrenia, and compared with responses from 26 
      healthy age-matched control subjects. Using high-density electrical scalp 
      recordings, we assessed the integrity of the visual P1 component across the two 
      groups. This study was conducted at St.Vincent's Psychiatric Hospital in 
      Fairview, Dublin, Ireland. RESULTS: Substantially reduced P1 amplitude was 
      demonstrated in the patient group compared to controls. The deficit was not 
      linked to age, length of illness or medication status. A small positive 
      correlation, accounting for about 11% of the variance, was found between P1 
      amplitude and clinical symptoms scales (BPRS and SANS). In addition, we found 
      that a slightly later (~110 ms) fronto-central component was relatively increased 
      in the patient group, and was inversely correlated with the occipital P1 
      amplitude in the patients, but not in the healthy control subjects. CONCLUSIONS: 
      Our findings clearly demonstrate a deficit in early visual processing in patients 
      with schizophrenia (with a large effect size; Cohen's d = 0.7) that is unrelated 
      to chronicity. The results are consistent with recent findings showing that the 
      P1 deficit is endophenotypic of the disorder and related to genetic risk factors 
      rather than the disease process itself.
FAU - Yeap, Sherlyn
AU  - Yeap S
AD  - The Cognitive Neurophysiology Laboratory, St. Vincent's Hospital, Richmond Road, 
      Fairview, Dublin 3, Ireland.
FAU - Kelly, Simon P
AU  - Kelly SP
FAU - Sehatpour, Pejman
AU  - Sehatpour P
FAU - Magno, Elena
AU  - Magno E
FAU - Garavan, Hugh
AU  - Garavan H
FAU - Thakore, Jogin H
AU  - Thakore JH
FAU - Foxe, John J
AU  - Foxe JJ
LA  - eng
GR  - R01 MH65350/MH/NIMH NIH HHS/United States
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20080526
PL  - Germany
TA  - Eur Arch Psychiatry Clin Neurosci
JT  - European archives of psychiatry and clinical neuroscience
JID - 9103030
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Analysis of Variance
MH  - Evoked Potentials, Visual/*physiology
MH  - Female
MH  - Frontal Lobe/physiopathology
MH  - Humans
MH  - Ireland
MH  - Male
MH  - Middle Aged
MH  - Neuropsychological Tests
MH  - Occipital Lobe/physiopathology
MH  - Photic Stimulation/methods
MH  - Psychiatric Status Rating Scales/*statistics & numerical data
MH  - Psychomotor Performance/physiology
MH  - Reaction Time/physiology
MH  - Schizophrenia/pathology/*physiopathology
MH  - *Schizophrenic Psychology
MH  - Time Factors
MH  - Visual Pathways/physiology
MH  - Visual Perception/*physiology
MH  - Young Adult
EDAT- 2008/05/28 09:00
MHDA- 2008/12/17 09:00
CRDT- 2008/05/28 09:00
PHST- 2007/11/08 00:00 [received]
PHST- 2008/01/17 00:00 [accepted]
PHST- 2008/05/28 09:00 [pubmed]
PHST- 2008/12/17 09:00 [medline]
PHST- 2008/05/28 09:00 [entrez]
AID - 10.1007/s00406-008-0802-2 [doi]
PST - ppublish
SO  - Eur Arch Psychiatry Clin Neurosci. 2008 Aug;258(5):305-16. doi: 
      10.1007/s00406-008-0802-2. Epub 2008 May 26.