PMID- 18504738
OWN - NLM
STAT- MEDLINE
DCOM- 20080919
LR  - 20080602
IS  - 1053-1807 (Print)
IS  - 1053-1807 (Linking)
VI  - 27
IP  - 6
DP  - 2008 Jun
TI  - Differential interictal activity of the precuneus/posterior cingulate cortex 
      revealed by resting state functional MRI at 3T in generalized vs. partial 
      seizure.
PG  - 1214-20
LID - 10.1002/jmri.21370 [doi]
AB  - PURPOSE: To characterize, using functional MRI (fMRI), the pattern of active 
      brain regions in the resting state in patients with epilepsy. MATERIALS AND 
      METHODS: We studied 28 patients with epilepsy, divided into a partial seizure 
      (PS; N = 9) and a generalized seizure group (GS; N = 19), and 34 control 
      subjects. Resting state fMRI was performed using a GE 3T scanner by collecting 
      200 volumes of echo-planar imaging (EPI) images with subjects relaxed, eyes 
      closed. Data were processed using a modification of the method of Fransson (Hum 
      Brain Mapp 2005;26:15-29), which reveals information on regional low-frequency 
      Blood Oxygenation Level Dependent (BOLD) signal oscillations in the resting state 
      without any a priori hypothesis. The significant active areas in brain were 
      identified with both individual and group analysis. RESULTS: Controls showed 
      active regions in the precuneus/posterior cingulate cortex (PCC) and medial 
      prefrontal cortex (MPFC)/ventral anterior cingulate cortex (vACC), theregions 
      associated with the brain "default mode." Similar active regions were observed in 
      PS, whereas GS showed no significant activation of precuneus/PCC. CONCLUSION: In 
      GS, the lack of activation in precuneus/PCC may partly account for their more 
      severe interictal deficits, compared to PS, in cognitive functions such as 
      concentration and memory.
CI  - 2008 Wiley-Liss, Inc
FAU - Lui, Su
AU  - Lui S
AD  - Huaxi MR Research Center, Department of Radiology, West China Hospital of Sichuan 
      University, West China School of Medicine, Chengdu, China.
FAU - Ouyang, Luo
AU  - Ouyang L
FAU - Chen, Qin
AU  - Chen Q
FAU - Huang, Xiaoqi
AU  - Huang X
FAU - Tang, Hehan
AU  - Tang H
FAU - Chen, Huafu
AU  - Chen H
FAU - Zhou, Dong
AU  - Zhou D
FAU - Kemp, Graham J
AU  - Kemp GJ
FAU - Gong, Qiyong
AU  - Gong Q
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Magn Reson Imaging
JT  - Journal of magnetic resonance imaging : JMRI
JID - 9105850
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Brain/*physiopathology
MH  - Brain Mapping/methods
MH  - Diagnosis, Differential
MH  - Echo-Planar Imaging/instrumentation/*methods
MH  - Electroencephalography/methods
MH  - Epilepsies, Partial/*diagnosis/*physiopathology
MH  - Epilepsy, Generalized/*diagnosis/*physiopathology
MH  - Female
MH  - Humans
MH  - Imaging, Three-Dimensional/methods
MH  - Magnetics
MH  - Male
MH  - Middle Aged
MH  - *Rest
EDAT- 2008/05/28 09:00
MHDA- 2008/09/20 09:00
CRDT- 2008/05/28 09:00
PHST- 2008/05/28 09:00 [pubmed]
PHST- 2008/09/20 09:00 [medline]
PHST- 2008/05/28 09:00 [entrez]
AID - 10.1002/jmri.21370 [doi]
PST - ppublish
SO  - J Magn Reson Imaging. 2008 Jun;27(6):1214-20. doi: 10.1002/jmri.21370.