PMID- 1850481
OWN - NLM
STAT- MEDLINE
DCOM- 19910524
LR  - 20181130
IS  - 0022-3565 (Print)
IS  - 0022-3565 (Linking)
VI  - 257
IP  - 1
DP  - 1991 Apr
TI  - Enhanced serotonergic transmission stimulates oxytocin secretion in conscious 
      male rats.
PG  - 95-9
AB  - The involvement of serotonin (5-HT) in oxytocin secretion was investigated in 
      this study. Pharmacologic agents that influence serotonergic transmission were 
      administered to conscious unrestrained male rats 30 min prior to sacrifice and 
      plasma oxytocin concentration was measured by radioimmunoassay. The d- and 
      l-stereoisomers of the 5-HT releaser fenfluramine significantly increased plasma 
      oxytocin in a dose-dependent manner. Oxytocin secretion was more potently 
      stimulated by d-fenfluramine than by l-fenfluramine. The 5-HT releaser 
      p-chloroamphetamine also increased plasma oxytocin. The following 5-HT agonists 
      increased plasma oxytocin concentration: the 5-HT1&2 agonist 
      m-chlorophenyl-piperazine [10-20 mg/kg intraperitoneally (i.p.)], the 5-HT1C&2 
      agonist 1-(2,5-dimethoxy-4-l-phenyl)-2-aminopropane (0.5-2.0 mg/kg i.p.) and the 
      5-HT1&2 agonist 1-piperazinyl-6-chloropyrazine (10 mg/kg i.p.). In contrast, the 
      5-HT1AB agonist 5-methoxy-3-(1,2,3,4-tetrahydro-4-pyridinyl)-1H-indole (0.2-5.0 
      mg/kg i.p.) did not increase oxytocin secretion. Pretreatment with the 5-HT1C&2 
      antagonist, 
      6-(2-(4-[bis(4-fluorophenyl)methylene]-1-piperidinyl)ethyl)-7-methyl-5H- 
      thiazolo(3(1)2-a)pyrimidin-5-one [2.5 mg/kg subcutaneously (s.c.)], 60 min before 
      injection of 1-piperazinyl-6-chloropyrazine attenuated, but did not completely 
      block, 1-piperazinyl-6-chloropyrazine-induced secretion of oxytocin. Both low and 
      high (0.01 and 0.1 mg/kg s.c.) doses of 
      6-(2-(4-[bis(4-fluorophenyl)methylene]-1-piperidinyl)ethyl)-7-methyl-5H- 
      thiazolo(3(1)2-a)pyrimidin-5-one or the 5-HT2 antagonist spiperone inhibited the 
      1-(2,5-dimethoxy-4-l-phenyl)-2-aminopropane-induced increases in plasma oxytocin. 
      These studies provide evidence that enhanced serotonergic transmission stimulates 
      oxytocin secretion and that 5-HT2 receptors contribute to this effect.
FAU - Saydoff, J A
AU  - Saydoff JA
AD  - Department of Comparative Biosciences, School of Veterinary Medicine, University 
      of Wisconsin, Madison.
FAU - Rittenhouse, P A
AU  - Rittenhouse PA
FAU - van de Kar, L D
AU  - van de Kar LD
FAU - Brownfield, M S
AU  - Brownfield MS
LA  - eng
GR  - R01 DA04865/DA/NIDA NIH HHS/United States
GR  - R01 MH45812-01/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Pharmacol Exp Ther
JT  - The Journal of pharmacology and experimental therapeutics
JID - 0376362
RN  - 0 (Piperazines)
RN  - 0 (Piperidines)
RN  - 0 (Receptors, Serotonin)
RN  - 145TFV465S (Ritanserin)
RN  - 333DO1RDJY (Serotonin)
RN  - 50-56-6 (Oxytocin)
RN  - REY0CNO998 (1-(3-chlorophenyl)piperazine)
SB  - IM
MH  - Animals
MH  - Male
MH  - Oxytocin/*metabolism
MH  - Piperazines/pharmacology
MH  - Piperidines/pharmacology
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Receptors, Serotonin/drug effects/physiology
MH  - Ritanserin
MH  - Serotonin/*physiology
MH  - Synaptic Transmission/*physiology
EDAT- 1991/04/01 00:00
MHDA- 1991/04/01 00:01
CRDT- 1991/04/01 00:00
PHST- 1991/04/01 00:00 [pubmed]
PHST- 1991/04/01 00:01 [medline]
PHST- 1991/04/01 00:00 [entrez]
PST - ppublish
SO  - J Pharmacol Exp Ther. 1991 Apr;257(1):95-9.