PMID- 18507093
OWN - NLM
STAT- MEDLINE
DCOM- 20080902
LR  - 20131121
IS  - 0172-6390 (Print)
IS  - 0172-6390 (Linking)
VI  - 55
IP  - 81
DP  - 2008 Jan-Feb
TI  - Persistent oxidative stress in the corpus mucosa is evoked by long-term treatment 
      of H. pylori-infected patients with proton pump inhibitors.
PG  - 138-41
AB  - BACKGROUND/AIMS: To examine the influence of long-term treatment of H. 
      pylori-infected patients with proton pump inhibitors (PPI) on the toxic oxidant 
      production in the stomach. METHODOLOGY: Eight H. pylori-positive patients with 
      gastric ulcer were enrolled, and tissue samples were obtained endoscopically from 
      the antrum and corpus. The tissue contents of neutrophil myeloperoxidase (MPO) 
      and oxygen-derived free radicals were quantified by ELISA and chemiluminescence 
      (ChL) assay. The H. pylori density in the tissue specimens was scored by 
      immunohistochemistry and the mucosal infiltration by neutrophils and monocytes 
      was scored by histopathology. The effects of PPI on these parameters were 
      evaluated by oral administration of lansoprazole (LPZ) at the dose of 30mg od for 
      8 weeks, followed by 15mg for 24 weeks. RESULTS: Eight-week treatment with LPZ 
      significantly increased the corpus ChL by 400%, which remained unchanged at this 
      level during the subsequent 24 weeks, but the antrum ChL decreased slightly 
      following LPZ-treatment. No significant changes in the mucosal MPO activity or 
      the histologically determined parameters of H. pylori density and 
      neutrophil/monocyte infiltration were observed in either portion of the stomach. 
      CONCLUSIONS: The mucosal oxidative stress level significantly increased in the 
      corpus mucosa after long-term treatment with LPZ, which may be independent of 
      inflammatory cell infiltration.
FAU - Suzuki, Masayuki
AU  - Suzuki M
AD  - Division of Gastroenterology, National Hospital Organization Tokyo Medical 
      Center, Meguro-ku, Tokyo, Japan. msuzuki@ntmc.hosp.go.jp
FAU - Tanaka, Shin
AU  - Tanaka S
FAU - Suzuki, Koichi
AU  - Suzuki K
FAU - Kitahora, Tetsuji
AU  - Kitahora T
FAU - Masaoka, Tatsuhiro
AU  - Masaoka T
FAU - Suzuki, Hidekazu
AU  - Suzuki H
FAU - Hibi, Toshifumi
AU  - Hibi T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Greece
TA  - Hepatogastroenterology
JT  - Hepato-gastroenterology
JID - 8007849
RN  - 0 (2-Pyridinylmethylsulfinylbenzimidazoles)
RN  - 0 (Proton Pump Inhibitors)
RN  - 0K5C5T2QPG (Lansoprazole)
RN  - EC 1.11.1.7 (Peroxidase)
SB  - IM
MH  - 2-Pyridinylmethylsulfinylbenzimidazoles/*administration & dosage
MH  - Adult
MH  - Aged
MH  - Helicobacter Infections/*drug therapy
MH  - *Helicobacter pylori
MH  - Humans
MH  - Intestinal Mucosa/*metabolism/microbiology
MH  - Lansoprazole
MH  - Luminescent Measurements
MH  - Male
MH  - Middle Aged
MH  - *Oxidative Stress/drug effects
MH  - Peroxidase/analysis
MH  - Proton Pump Inhibitors/*administration & dosage
EDAT- 2008/05/30 09:00
MHDA- 2008/09/03 09:00
CRDT- 2008/05/30 09:00
PHST- 2008/05/30 09:00 [pubmed]
PHST- 2008/09/03 09:00 [medline]
PHST- 2008/05/30 09:00 [entrez]
PST - ppublish
SO  - Hepatogastroenterology. 2008 Jan-Feb;55(81):138-41.