PMID- 18507785
OWN - NLM
STAT- MEDLINE
DCOM- 20091112
LR  - 20090402
IS  - 1399-3038 (Electronic)
IS  - 0905-6157 (Linking)
VI  - 20
IP  - 2
DP  - 2009 Mar
TI  - Association of early growth response-1 gene polymorphisms with total IgE and 
      atopy in asthmatic children.
PG  - 142-50
LID - 10.1111/j.1399-3038.2008.00757.x [doi]
AB  - Early growth response-1 (Egr-1) is expressed in human airways and found to 
      modulate tumor necrosis factor, immunoglobulin E (IgE), airway responsiveness, 
      and interleukin-13-induced inflammation in mice. We investigated the effects of 
      Chinese-tagging single nucleotide polymorphisms (SNPs) of Egr-1 on asthma traits 
      in 298 Chinese asthmatic children and 175 controls, and a replication community 
      cohort of 191 controls. Tag SNP (-4071 A-->G) and three additional SNPs (-1427 
      C-->T, -151 C-->T and IVS1 -42 C-->T) were genotyped by restriction fragment 
      length polymorphism (RFLP). Significant associations were found between plasma 
      total IgE concentration and -4071 A-->G (p = 0.008) and IVS1 -42 C-->T (p = 
      0.027) in asthmatic patients. After Bonferroni correction, only -4071 A-->G 
      showed significant association. Multivariate regression analysis confirmed this 
      significant association with a standardized coefficient beta of 0.156 (95% CI: 
      0.046-0.317; p = 0.009) in asthmatics among the three SNPs with age and 
      gender-adjusted. In -4071 A-->G, IgE(log) was significantly higher in patients 
      with the GG genotype than the AA genotype (p = 0.009). In addition, -4071 A-->G 
      was significantly associated with atopy (p = 0.016) and high total IgE 
      concentration (p = 0.030) among asthmatics. Patients with the G allele had a 
      3.5-fold risk of having atopy and a 2.0-fold risk of having high total IgE 
      concentration than those homozygous for the A allele. This is the first report to 
      show significant association of Egr-1 polymorphisms with plasma total IgE and 
      atopy in asthmatics. It may help to explore the pharmacogenetics of Egr-1 
      inhibitors.
FAU - Chan, Iris H S
AU  - Chan IH
AD  - Department of Chemical Pathology, The Chinese University of Hong Kong, Hong Kong.
FAU - Tang, Nelson L S
AU  - Tang NL
FAU - Leung, Ting F
AU  - Leung TF
FAU - Huang, W
AU  - Huang W
FAU - Lam, Yvonne Y O
AU  - Lam YY
FAU - Wong, Gary W K
AU  - Wong GW
FAU - Chan, Juliana C N
AU  - Chan JC
FAU - Chan, Michael H M
AU  - Chan MH
FAU - Wong, Chun K
AU  - Wong CK
FAU - Zhang, Ya P
AU  - Zhang YP
FAU - Lam, Christopher W K
AU  - Lam CW
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080528
PL  - England
TA  - Pediatr Allergy Immunol
JT  - Pediatric allergy and immunology : official publication of the European Society 
      of Pediatric Allergy and Immunology
JID - 9106718
RN  - 0 (Antigens, Dermatophagoides)
RN  - 0 (Early Growth Response Protein 1)
RN  - 0 (Epitopes)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Animals
MH  - Antigens, Dermatophagoides/*immunology
MH  - Asthma/blood/*genetics/*immunology
MH  - Cats/immunology
MH  - Child
MH  - Child, Preschool
MH  - Cockroaches/immunology
MH  - Dermatophagoides pteronyssinus/immunology
MH  - Dogs/immunology
MH  - Early Growth Response Protein 1/*genetics/immunology
MH  - Epitopes
MH  - Female
MH  - Genotype
MH  - Humans
MH  - Immunoglobulin E/*blood
MH  - Linkage Disequilibrium
MH  - Male
MH  - Polymorphism, Single Nucleotide
MH  - Spirometry
EDAT- 2008/05/30 09:00
MHDA- 2009/11/13 06:00
CRDT- 2008/05/30 09:00
PHST- 2008/05/30 09:00 [pubmed]
PHST- 2009/11/13 06:00 [medline]
PHST- 2008/05/30 09:00 [entrez]
AID - PAI757 [pii]
AID - 10.1111/j.1399-3038.2008.00757.x [doi]
PST - ppublish
SO  - Pediatr Allergy Immunol. 2009 Mar;20(2):142-50. doi: 
      10.1111/j.1399-3038.2008.00757.x. Epub 2008 May 28.