PMID- 18507811
OWN - NLM
STAT- MEDLINE
DCOM- 20081208
LR  - 20220309
IS  - 1600-0854 (Electronic)
IS  - 1398-9219 (Print)
IS  - 1398-9219 (Linking)
VI  - 9
IP  - 9
DP  - 2008 Sep
TI  - Trafficking of vesicular neurotransmitter transporters.
PG  - 1425-36
LID - 10.1111/j.1600-0854.2008.00771.x [doi]
AB  - Vesicular neurotransmitter transporters are required for the storage of all 
      classical and amino acid neurotransmitters in secretory vesicles. Transporter 
      expression can influence neurotransmitter storage and release, and trafficking 
      targets the transporters to different types of secretory vesicles. Vesicular 
      transporters traffic to synaptic vesicles (SVs) as well as large dense core 
      vesicles and are recycled to SVs at the nerve terminal. Some of the intrinsic 
      signals for these trafficking events have been defined and include a dileucine 
      motif present in multiple transporter subtypes, an acidic cluster in the neural 
      isoform of the vesicular monoamine transporter (VMAT) 2 and a polyproline motif 
      in the vesicular glutamate transporter (VGLUT) 1. The sorting of VMAT2 and the 
      vesicular acetylcholine transporter to secretory vesicles is regulated by 
      phosphorylation. In addition, VGLUT1 uses alternative endocytic pathways for 
      recycling back to SVs following exocytosis. Regulation of these sorting events 
      has the potential to influence synaptic transmission and behavior.
FAU - Fei, Hao
AU  - Fei H
AD  - Departments of Psychiatry and Neurobiology, Gonda Goldschmied Neuroscience and 
      Genetics Research Center, David Geffen School of Medicine at UCLA, Los Angeles, 
      CA 90095-1761, USA.
FAU - Grygoruk, Anna
AU  - Grygoruk A
FAU - Brooks, Elizabeth S
AU  - Brooks ES
FAU - Chen, Audrey
AU  - Chen A
FAU - Krantz, David E
AU  - Krantz DE
LA  - eng
GR  - R01 ES015747/ES/NIEHS NIH HHS/United States
GR  - P01 ES016732-010002/ES/NIEHS NIH HHS/United States
GR  - ES015747/ES/NIEHS NIH HHS/United States
GR  - R01 NS051453/NS/NINDS NIH HHS/United States
GR  - T32/MH019384/MH/NIMH NIH HHS/United States
GR  - R01 MH076900/MH/NIMH NIH HHS/United States
GR  - R01 ES015747-03S2/ES/NIEHS NIH HHS/United States
GR  - GM07185/GM/NIGMS NIH HHS/United States
GR  - MH076900/MH/NIMH NIH HHS/United States
GR  - R01 NS051453-01/NS/NINDS NIH HHS/United States
GR  - P01 ES016732/ES/NIEHS NIH HHS/United States
GR  - R01 MH076900-03/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20080526
PL  - England
TA  - Traffic
JT  - Traffic (Copenhagen, Denmark)
JID - 100939340
RN  - 0 (Neurotransmitter Agents)
RN  - 0 (Neurotransmitter Transport Proteins)
SB  - IM
MH  - Animals
MH  - Endocytosis/physiology
MH  - Humans
MH  - Neurotransmitter Agents/*metabolism
MH  - Neurotransmitter Transport Proteins/*metabolism
MH  - Protein Transport
MH  - Secretory Vesicles/*metabolism/physiology
MH  - Synaptic Transmission/physiology
PMC - PMC2897747
MID - NIHMS210973
EDAT- 2008/05/30 09:00
MHDA- 2008/12/17 09:00
PMCR- 2010/07/06
CRDT- 2008/05/30 09:00
PHST- 2008/05/30 09:00 [pubmed]
PHST- 2008/12/17 09:00 [medline]
PHST- 2008/05/30 09:00 [entrez]
PHST- 2010/07/06 00:00 [pmc-release]
AID - TRA771 [pii]
AID - 10.1111/j.1600-0854.2008.00771.x [doi]
PST - ppublish
SO  - Traffic. 2008 Sep;9(9):1425-36. doi: 10.1111/j.1600-0854.2008.00771.x. Epub 2008 
      May 26.