PMID- 18508652
OWN - NLM
STAT- MEDLINE
DCOM- 20080919
LR  - 20190902
IS  - 1093-9946 (Print)
IS  - 1093-4715 (Linking)
VI  - 13
DP  - 2008 May 1
TI  - Virus associated innate immunity in liver.
PG  - 6183-92
AB  - Dendritic cells (DCs) sense virus via toll-like receptors (TLR) or retinoic acid 
      inducible gene-I (RIG-I) and evoke a cascade of immune reactions. In myeloid DC 
      (MDC) from hepatitis C virus (HCV)-infected patients, the levels of 
      TLR/RIG-I-mediated IFN-beta or TNF-alfa induction are lower than those in 
      uninfected donors, suggesting that their signal transduction in MDC is impaired. 
      Dendritic cells in HCV infection are unresponsive to interferon (IFN)-alfa, thus 
      failing to enhance MHC class-I related chain A/B and subsequent NK cell 
      activation. Alternatively, NK cells from the patients down-regulate DC in the 
      presence of HLA-E-expressing hepatocytes by secreting IL-10 and TGF-beta1. Such 
      functional alteration of NK cells in HCV infection is ascribed to the enhanced 
      expression of NKG2A/CD94. Activated NKT cells from the patients produce higher 
      levels of IL-13 but comparable IFN-gamma with those from controls, showing their 
      bias to Th2-type. In pegylated IFN-alfa/ribavirin therapy for chronic hepatitis 
      C, improved DC function is related with successful HCV eradication. In 
      conclusion, cross-talks among DCs and innate lymphocytes are critical in shaping 
      immune response against HCV, either spontaneously or therapeutically.
FAU - Kanto, Tatsuya
AU  - Kanto T
AD  - Department of Gastroenterology, Osaka University Graduate School of Medicine, 
      Suita, Japan. kantot@gh.med.osaka-u.ac.jp
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20080501
PL  - United States
TA  - Front Biosci
JT  - Frontiers in bioscience : a journal and virtual library
JID - 9709506
RN  - 0 (Toll-Like Receptors)
SB  - IM
MH  - Dendritic Cells/classification/immunology
MH  - Hepatitis C/*immunology
MH  - Hepatitis, Viral, Human/*immunology
MH  - Humans
MH  - *Immunity, Innate
MH  - Killer Cells, Natural/immunology
MH  - Liver/*immunology/*virology
MH  - Lymphocyte Subsets/immunology
MH  - T-Lymphocytes/immunology
MH  - Toll-Like Receptors/physiology
RF  - 50
EDAT- 2008/05/30 09:00
MHDA- 2008/09/20 09:00
CRDT- 2008/05/30 09:00
PHST- 2008/05/30 09:00 [pubmed]
PHST- 2008/09/20 09:00 [medline]
PHST- 2008/05/30 09:00 [entrez]
AID - 3146 [pii]
AID - 10.2741/3146 [doi]
PST - epublish
SO  - Front Biosci. 2008 May 1;13:6183-92. doi: 10.2741/3146.