PMID- 18509277
OWN - NLM
STAT- MEDLINE
DCOM- 20080801
LR  - 20181201
IS  - 1234-1010 (Print)
IS  - 1234-1010 (Linking)
VI  - 14
IP  - 6
DP  - 2008 Jun
TI  - Melatonin secretion and non-specific immune responses are differentially 
      expressed in corticotropin-dependent and corticotropin-independent Cushing's 
      syndrome.
PG  - CR327-332
AB  - BACKGROUND: This study was done to clarify the relation between melatonin 
      secretion and the hypothalamic-pituitary-adrenal axis. MATERIAL/METHODS: In this 
      clinical study using a follow-up approach, we investigated the circadian 
      melatonin secretion and immune parameters of patients with 
      corticotropin-dependent (Cushing's disease) and corticotropin-independent 
      Cushing's syndrome. Plasma hormone concentrations, interleukin 1-beta (IL-1beta) 
      and total immunoglobulin E (IgE) were determined before surgical treatment and 
      during remission of the syndrome 1 year later. RESULTS: Patients with Cushing's 
      disease showed mean nocturnal and diurnal melatonin plasma values similar to 
      those of healthy controls. Only the midday level of patients (taken at 12:00) was 
      significantly higher in comparison to controls (35.44+/-19.5 pg/mL vs 
      17.14+/-3.58 pg/mL; P<0.05). In contrast, patients with corticotropin-independent 
      Cushing's syndrome had significantly lower mean nocturnal and significantly 
      higher mean diurnal melatonin levels (52.8+/-17.7 pg/mL and 59.2+/-28.7 pg/mL, 
      respectively; P<0.05 and P<0.05) as compared with corresponding values for 
      controls (101.4+/-43.1 pg/mL and 28.9+/-11.7 pg/mL, respectively). In the last 
      group of patients, significantly higher mean IL1beta and plasma IgE 
      concentrations (3.30+/-1.72 pg/mL and 527.8+/-474.0 IU/mL, respectively) were 
      observed compared with controls (1.43+/-0.95 pg/mL and 35.7+/-32.1 IU/mL, 
      respectively) (P<0.05). Remission of the hypercortisolism in these patients 
      resulted in restoration of circadian melatonin secretion and significant 
      reductions in plasma IL1beta and total IgE levels. CONCLUSIONS: Our results 
      demonstrate a specific mode of melatonin secretion and different nonspecific 
      immune responses in the 2 investigated forms of hypercortisolism, specifically, 
      corticotropin-dependent and corticotropin-independent Cushing's syndrome.
FAU - Tomova, Analia
AU  - Tomova A
AD  - Clinical Center of Endocrinology and Gerontology, Medical University, Damian 
      Gruev Str. 6, Sofia, Bulgaria.
FAU - Kumanov, Philip
AU  - Kumanov P
FAU - Robeva, Ralitsa
AU  - Robeva R
FAU - Manchev, Stefan
AU  - Manchev S
FAU - Konakchieva, Rossitza
AU  - Konakchieva R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Med Sci Monit
JT  - Medical science monitor : international medical journal of experimental and 
      clinical research
JID - 9609063
RN  - 0 (Interleukin-1beta)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 9002-60-2 (Adrenocorticotropic Hormone)
RN  - JL5DK93RCL (Melatonin)
SB  - IM
MH  - Adrenocorticotropic Hormone/*metabolism
MH  - Adult
MH  - Case-Control Studies
MH  - Cushing Syndrome/*immunology
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/blood
MH  - Interleukin-1beta/blood
MH  - Melatonin/*metabolism
EDAT- 2008/05/30 09:00
MHDA- 2008/08/02 09:00
CRDT- 2008/05/30 09:00
PHST- 2008/05/30 09:00 [pubmed]
PHST- 2008/08/02 09:00 [medline]
PHST- 2008/05/30 09:00 [entrez]
AID - 859037 [pii]
PST - ppublish
SO  - Med Sci Monit. 2008 Jun;14(6):CR327-332.