PMID- 18509363
OWN - NLM
STAT- MEDLINE
DCOM- 20081022
LR  - 20090620
IS  - 1523-1747 (Electronic)
IS  - 0022-202X (Linking)
VI  - 128
IP  - 10
DP  - 2008 Oct
TI  - Primary cutaneous T-cell lymphomas do not show specific NAV3 gene deletion or 
      translocation.
PG  - 2458-66
LID - 10.1038/jid.2008.113 [doi]
AB  - The mapping of a balanced t(12;18)(q21;q21.2) translocation in a Sezary syndrome 
      (SS) case led Karenko et al. to identify NAV3 gene (12q21-22) deletion by 
      interphase fluorescence in situ hybridization (FISH) in 15/21 patients with 
      mycosis fungoides (MF) or SS. To determine whether the NAV3 deletion is the 
      result of a specific gene breakpoint, we used FISH with dual-color split or 
      break-apart bacterial artificial chromosome (BAC) probes covering the NAV3 locus. 
      A total of 31 samples (18 skin, 11 blood, 1 lymph node, and 1 spleen) from 24 
      patients with advanced MF/SS (18 with large-cell transformation) were studied. 
      Chromosome 12 imbalances were analyzed by comparative genomic hybridization (CGH) 
      array with a 3K BAC probes in 24 samples from 22 patients. Both normal FISH and 
      CGH array patterns were observed in 22 samples from 18 patients. In 6 patients, 
      abnormal patterns were observed with an abnormal number of chromosome 12 set in 5 
      of them. Chromosome 12 structural abnormalities were seen in four of these six 
      patients. An imbalanced FISH pattern between NAV3 and pericentromeric control 
      probes was seen in three patients in accordance with CGH array data (one with a 
      pericentromeric deletion and two with a large 12q deletion including NAV3). No 
      NAV3 specific breakpoint or partial deletion was detected.
FAU - Marty, Marion
AU  - Marty M
AD  - Histology and Molecular Pathology Laboratory, University Bordeaux, Bordeaux, 
      France.
FAU - Prochazkova, Martina
AU  - Prochazkova M
FAU - Laharanne, Elodie
AU  - Laharanne E
FAU - Chevret, Edith
AU  - Chevret E
FAU - Longy, Michel
AU  - Longy M
FAU - Jouary, Thomas
AU  - Jouary T
FAU - Vergier, Beatrice
AU  - Vergier B
FAU - Beylot-Barry, Marie
AU  - Beylot-Barry M
FAU - Merlio, Jean-Philippe
AU  - Merlio JP
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080529
PL  - United States
TA  - J Invest Dermatol
JT  - The Journal of investigative dermatology
JID - 0426720
RN  - 0 (Membrane Proteins)
RN  - 0 (NAV3 protein, human)
RN  - 0 (Nerve Tissue Proteins)
SB  - IM
EIN - J Invest Dermatol. 2009 Jun;129(6):1591. Philippe, Merlio Jean [corrected to 
      Merlio, Jean-Philippe]
MH  - Aged
MH  - Chromosome Aberrations
MH  - Chromosomes, Artificial, Bacterial
MH  - Chromosomes, Human, Pair 12
MH  - Female
MH  - *Gene Deletion
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Membrane Proteins/*genetics
MH  - Mycosis Fungoides/*genetics
MH  - Nerve Tissue Proteins/*genetics
MH  - Nucleic Acid Hybridization
MH  - Sezary Syndrome/*genetics
MH  - Skin Neoplasms/*genetics
MH  - *Translocation, Genetic
MH  - Tumor Cells, Cultured
EDAT- 2008/05/30 09:00
MHDA- 2008/10/23 09:00
CRDT- 2008/05/30 09:00
PHST- 2008/05/30 09:00 [pubmed]
PHST- 2008/10/23 09:00 [medline]
PHST- 2008/05/30 09:00 [entrez]
AID - S0022-202X(15)33647-2 [pii]
AID - 10.1038/jid.2008.113 [doi]
PST - ppublish
SO  - J Invest Dermatol. 2008 Oct;128(10):2458-66. doi: 10.1038/jid.2008.113. Epub 2008 
      May 29.